Effect of solution properties on nanofibrous structure of electrospun poly(lactic-co-glycolic acid)

Young You, Seung Jin Lee, Byung Moo Min, Won Ho Park

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Electrospinning of poly(lactic-co-glycolic acid) (PLGA) in chloroform or 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was investigated, focusing on its solution parameters, to develop nonwoven biodegradable nanofibrous structures for tissue engineering. PLGA nanofibers were obtained by electrospinning of 15 wt % PLGA solution and the resulting average fiber diameters were varied with the range of 270-760 nm, depending on solution property. When small amounts of benzyl triethylammonium chloride (BTEAC) was added to the PLGA/chloroform solution, the average diameter was decreased from 760 to 450 nm and the fibers were densely amounted in a straight shape. In addi tion, the average fiber diameter (270 nm) of nanofibers electrospun from polar HFIP solvent was much smaller than that (760 nm) of nanofibers electrospun from nonpolar chloroform solvent. Therefore, it could be concluded that conductivity or dielectric constant of the PLGA solution was a major parameter affecting the morphology and diameter of the electrospun PLGA fibers.

Original languageEnglish
Pages (from-to)1214-1221
Number of pages8
JournalJournal of Applied Polymer Science
Volume99
Issue number3
DOIs
StatePublished - 5 Feb 2006

Keywords

  • Additive
  • Electrospinning
  • Nanofiber
  • Polyesters
  • Solution properties

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