Effect of SKI 306X, a New herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study

Young Bok Jung, Kwon Jae Roh, Jin A. Jung, Kiwon Jung, Hunseung Yoo, Yong Baik Cho, Wie Jong Kwak, Dae Kee Kim, Key H. Kirn, Chang Kyun Han

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

SKI 306X is a purified extract from a mixture of three oriental herbal medicines (Clematis mandshurica, Trichosanthes kirilowii and Pnmella vtilgaris) that have been widely used for the treatment of inflammatory diseases such as lymphadenitis and arthritis in far East Asia. A double-blind, controlled study was performed to evaluate the efficacy and safety of SKI 306X with placebo in 96 patients with classical osteoarthritis of the knee. Patients were randomized to four treatment groups: placebo, 200 mg, 400 mg and 600 mg of SKI 306X t.i.d.. Clinical efficacy and safety were evaluated for4 weeks continuous treatment. SKI 306X demonstrated its clinical efficacy, as assessed by 100 mm visual analogue scale (VAS), Lequesne index and patients' and investigators opinion of the therapeutic effect compared with placebo (p<0.01). No significant adverse events were observed in patients treated with SKI 306X. This study demonstrated that SKI 306X, a new herbal anti-arthritic agent provided clinical efficacy in patients with osteoarthritis.

Original languageEnglish
Pages (from-to)485-491
Number of pages7
JournalAmerican Journal of Chinese Medicine
Volume29
Issue number3-4
DOIs
StatePublished - 2001

Fingerprint

Dive into the research topics of 'Effect of SKI 306X, a New herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study'. Together they form a unique fingerprint.

Cite this