Effect of preoperative urodynamic detrusor overactivity on post-prostatectomy incontinence: a systematic review and meta-analysis

Myong Kim, Myungchan Park, Myungsun Shim, Seung Kwon Choi, Sang Mi Lee, Eun Sik Lee, Cheryn Song, Myung Soo Choo, Hanjong Ahn

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Purpose: To investigate whether preoperative urodynamic detrusor overactivity (DO) contributes to post-prostatectomy incontinence (PPI). Methods: We systematically searched the online PubMed, Embase, and Cochrane Library databases spanning the period of January 1989 to December 2014. Results: A total of nine articles met the eligibility criteria for this systematic review. The eligible studies included a total of 457 patients with a median number of 58 patients per study (range 17–92). Of the nine studies, five conducted open retropubic radical prostatectomy (RRP), two performed robot-assisted laparoscopic prostatectomy (RALP), and two others utilized multiple modalities. PPI was more likely to occur in patients with preoperative DO [pooled odds ratio (OR) 2.30; 95 % confidence interval (CI) 1.39–3.82; studies 9; participants 419], as compared to patients who were DO negative. Sensitivity analysis using the subgroups of RRP (OR 2.32; 95 % CI 1.11–4.85), RALP (OR 3.41; 95 % CI 1.55–7.47), DO defined as any amplitude of involuntary contraction (OR 2.32; 95 % CI 1.11–4.85), no postoperative intervention (OR 2.32; 95 % CI 1.11–4.85), and outcome evaluation after 6 months (OR 2.32; 95 % CI 1.11–4.85) demonstrated consistent results. Although some comparisons showed inter-study heterogeneity, there was no clear evidence of publication bias in this meta-analysis. Conclusions: Our meta-analysis results suggest that preoperative DO is another possible underlying mechanism for PPI.

Original languageEnglish
Pages (from-to)53-63
Number of pages11
JournalInternational Urology and Nephrology
Issue number1
StatePublished - 1 Jan 2016

Bibliographical note

Publisher Copyright:
© 2015, Springer Science+Business Media Dordrecht.


  • Detrusor overactivity
  • Incontinence
  • Radical prostatectomy
  • Urodynamic study


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