TY - JOUR
T1 - Effect of postoperative radiotherapy on survival in duodenal adenocarcinoma
T2 - a propensity score-adjusted analysis of Surveillance, Epidemiology, and End Results database
AU - Lim, Yu Jin
AU - Kim, Kyubo
N1 - Publisher Copyright:
© 2017, Japan Society of Clinical Oncology.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Purpose: The use of adjuvant treatment has not been sufficiently investigated in duodenal adenocarcinoma. This study evaluated the effect of postoperative radiotherapy (PORT) on survival outcomes in this rare malignancy. Methods: We identified patients who were diagnosed between 2004 and 2013 in the Surveillance, Epidemiology, and End Results database. Overall survival (OS) and disease-specific survival (DSS) were analyzed before and after propensity score matching. Results: Among the 701 eligible patients, 116 (17%) underwent PORT. There were no significant differences in OS and DSS according to receipt of PORT in the unmatched population (P = 0.982 and 0.496, respectively), whereas the propensity-matched analysis showed improved OS and DSS with PORT (P = 0.053 and 0.019, respectively). No receipt of PORT was an independent poor prognostic factor in multivariate analysis of both OS (P = 0.022) and DSS (P = 0.005). The potential survival benefits of PORT were observed in subgroups of T4 stage, larger tumor size, higher lymph node ratio, and total/radical resection. Conclusions: We provide useful insights into the therapeutic role of PORT in adenocarcinoma of the duodenum. Adjuvant strategy with PORT needs to be considered in locally advanced tumors.
AB - Purpose: The use of adjuvant treatment has not been sufficiently investigated in duodenal adenocarcinoma. This study evaluated the effect of postoperative radiotherapy (PORT) on survival outcomes in this rare malignancy. Methods: We identified patients who were diagnosed between 2004 and 2013 in the Surveillance, Epidemiology, and End Results database. Overall survival (OS) and disease-specific survival (DSS) were analyzed before and after propensity score matching. Results: Among the 701 eligible patients, 116 (17%) underwent PORT. There were no significant differences in OS and DSS according to receipt of PORT in the unmatched population (P = 0.982 and 0.496, respectively), whereas the propensity-matched analysis showed improved OS and DSS with PORT (P = 0.053 and 0.019, respectively). No receipt of PORT was an independent poor prognostic factor in multivariate analysis of both OS (P = 0.022) and DSS (P = 0.005). The potential survival benefits of PORT were observed in subgroups of T4 stage, larger tumor size, higher lymph node ratio, and total/radical resection. Conclusions: We provide useful insights into the therapeutic role of PORT in adenocarcinoma of the duodenum. Adjuvant strategy with PORT needs to be considered in locally advanced tumors.
KW - Adjuvant radiotherapy
KW - Duodenal neoplasms
KW - Prognosis
KW - Propensity score
KW - Survival analysis
UR - http://www.scopus.com/inward/record.url?scp=85038361570&partnerID=8YFLogxK
U2 - 10.1007/s10147-017-1226-7
DO - 10.1007/s10147-017-1226-7
M3 - Article
C2 - 29260430
AN - SCOPUS:85038361570
SN - 1341-9625
VL - 23
SP - 473
EP - 481
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 3
ER -