Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress

Sunwha Park; Eunjin Kwon; Gain Lee; Young Ah You; Soo Min Kim; Young Min Hur; Sooyoung Jung; Yongho Jee; Mi Hye Park; Sung Hun Na; Young Han Kim; Geum Joon Cho; Jin Gon Bae; Soo Jeong Lee; Sun Hwa Lee; Young Ju Kim

doi:10.3390/antiox12111916

Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress

Sunwha Park, Eunjin Kwon, Gain Lee, Young Ah You, Soo Min Kim, Young Min Hur, Sooyoung Jung, Yongho Jee, Mi Hye Park, Sung Hun Na, Young Han Kim, Geum Joon Cho, Jin Gon Bae, Soo Jeong Lee, Sun Hwa Lee, Young Ju Kim

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Particulate matter 2.5 (PM_2.5) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM_2.5 affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM_2.5 exposure levels. As a multicenter prospective cohort study, we measured the indoor PM_2.5 concentration and inflammatory and oxidative stress markers. The PM_2.5 concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m³, which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m³) (p = 0.02). When the newborns were divided by sex, the PM_2.5 concentration of the LBW group was 27.89 μg/m³ in male infants, which was significantly higher than that of the NBW group (26.26 μg/m³) (p = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (p < 0.01, p = 0.01). This study showed an association between PM_2.5, oxidative stress, and fetal growth, with the PTB group being more vulnerable.

Original language	English
Article number	1916
Journal	Antioxidants
Volume	12
Issue number	11
DOIs	https://doi.org/10.3390/antiox12111916
State	Published - Nov 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

8-hydroxy-2-deoxyguanosine
biomarker
indoor air
low birth weight
particulate matter
preterm birth
sex difference
small for gestational age

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title = "Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress",

abstract = "Particulate matter 2.5 (PM2.5) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM2.5 affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM2.5 exposure levels. As a multicenter prospective cohort study, we measured the indoor PM2.5 concentration and inflammatory and oxidative stress markers. The PM2.5 concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m3, which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m3) (p = 0.02). When the newborns were divided by sex, the PM2.5 concentration of the LBW group was 27.89 μg/m3 in male infants, which was significantly higher than that of the NBW group (26.26 μg/m3) (p = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (p < 0.01, p = 0.01). This study showed an association between PM2.5, oxidative stress, and fetal growth, with the PTB group being more vulnerable.",

keywords = "8-hydroxy-2-deoxyguanosine, biomarker, indoor air, low birth weight, particulate matter, preterm birth, sex difference, small for gestational age",

author = "Sunwha Park and Eunjin Kwon and Gain Lee and You, {Young Ah} and Kim, {Soo Min} and Hur, {Young Min} and Sooyoung Jung and Yongho Jee and Park, {Mi Hye} and Na, {Sung Hun} and Kim, {Young Han} and Cho, {Geum Joon} and Bae, {Jin Gon} and Lee, {Soo Jeong} and Lee, {Sun Hwa} and Kim, {Young Ju}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = nov,

doi = "10.3390/antiox12111916",

language = "English",

volume = "12",

journal = "Antioxidants",

issn = "2076-3921",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress

AU - Park, Sunwha

AU - Kwon, Eunjin

AU - Lee, Gain

AU - You, Young Ah

AU - Kim, Soo Min

AU - Hur, Young Min

AU - Jung, Sooyoung

AU - Jee, Yongho

AU - Park, Mi Hye

AU - Na, Sung Hun

AU - Kim, Young Han

AU - Cho, Geum Joon

AU - Bae, Jin Gon

AU - Lee, Soo Jeong

AU - Lee, Sun Hwa

AU - Kim, Young Ju

PY - 2023/11

Y1 - 2023/11

N2 - Particulate matter 2.5 (PM2.5) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM2.5 affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM2.5 exposure levels. As a multicenter prospective cohort study, we measured the indoor PM2.5 concentration and inflammatory and oxidative stress markers. The PM2.5 concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m3, which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m3) (p = 0.02). When the newborns were divided by sex, the PM2.5 concentration of the LBW group was 27.89 μg/m3 in male infants, which was significantly higher than that of the NBW group (26.26 μg/m3) (p = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (p < 0.01, p = 0.01). This study showed an association between PM2.5, oxidative stress, and fetal growth, with the PTB group being more vulnerable.

AB - Particulate matter 2.5 (PM2.5) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM2.5 affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM2.5 exposure levels. As a multicenter prospective cohort study, we measured the indoor PM2.5 concentration and inflammatory and oxidative stress markers. The PM2.5 concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m3, which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m3) (p = 0.02). When the newborns were divided by sex, the PM2.5 concentration of the LBW group was 27.89 μg/m3 in male infants, which was significantly higher than that of the NBW group (26.26 μg/m3) (p = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (p < 0.01, p = 0.01). This study showed an association between PM2.5, oxidative stress, and fetal growth, with the PTB group being more vulnerable.

KW - 8-hydroxy-2-deoxyguanosine

KW - biomarker

KW - indoor air

KW - low birth weight

KW - particulate matter

KW - preterm birth

KW - sex difference

KW - small for gestational age

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U2 - 10.3390/antiox12111916

DO - 10.3390/antiox12111916

M3 - Article

AN - SCOPUS:85178348990

SN - 2076-3921

VL - 12

JO - Antioxidants

JF - Antioxidants

IS - 11

M1 - 1916

ER -

Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress

Abstract

Bibliographical note

Keywords

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