Effect of oryung-san, a Korean traditional diuretic, on the pharmacokinetics of intravenous cefazolin in rats

J. Y. Rhie; Soon Ku Young Soon Ku

Effect of oryung-san, a Korean traditional diuretic, on the pharmacokinetics of intravenous cefazolin in rats

J. Y. Rhie
, Soon Ku Young Soon Ku

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of oryung-san (OS), a Korean traditional diuretic, on the renal excretion of intravenous cefazolin (CEZ) was investigated in rats. In OS-pre-treated rats, the cumulative 6-hr urinary excretion of cefazolin was significantly greater (4460 versus 3340 μg) and renal clearance was significantly faster (7.74 versus 4.90 ml/min/kg). This could be due to increase in unbound fraction of cefazolin in plasma and significant increase in cumulative 6-hr urine output (6.20 versus 3.96 ml) in OS-pretreated rats.

Original language	English
Pages (from-to)	95-103
Number of pages	9
Journal	Research Communications in Pharmacology and Toxicology
Volume	4
Issue number	1-2
State	Published - 1999

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title = "Effect of oryung-san, a Korean traditional diuretic, on the pharmacokinetics of intravenous cefazolin in rats",

abstract = "The effect of oryung-san (OS), a Korean traditional diuretic, on the renal excretion of intravenous cefazolin (CEZ) was investigated in rats. In OS-pre-treated rats, the cumulative 6-hr urinary excretion of cefazolin was significantly greater (4460 versus 3340 μg) and renal clearance was significantly faster (7.74 versus 4.90 ml/min/kg). This could be due to increase in unbound fraction of cefazolin in plasma and significant increase in cumulative 6-hr urine output (6.20 versus 3.96 ml) in OS-pretreated rats.",

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language = "English",

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journal = "Research Communications in Pharmacology and Toxicology",

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T1 - Effect of oryung-san, a Korean traditional diuretic, on the pharmacokinetics of intravenous cefazolin in rats

AU - Rhie, J. Y.

AU - Young Soon Ku, Soon Ku

PY - 1999

Y1 - 1999

N2 - The effect of oryung-san (OS), a Korean traditional diuretic, on the renal excretion of intravenous cefazolin (CEZ) was investigated in rats. In OS-pre-treated rats, the cumulative 6-hr urinary excretion of cefazolin was significantly greater (4460 versus 3340 μg) and renal clearance was significantly faster (7.74 versus 4.90 ml/min/kg). This could be due to increase in unbound fraction of cefazolin in plasma and significant increase in cumulative 6-hr urine output (6.20 versus 3.96 ml) in OS-pretreated rats.

AB - The effect of oryung-san (OS), a Korean traditional diuretic, on the renal excretion of intravenous cefazolin (CEZ) was investigated in rats. In OS-pre-treated rats, the cumulative 6-hr urinary excretion of cefazolin was significantly greater (4460 versus 3340 μg) and renal clearance was significantly faster (7.74 versus 4.90 ml/min/kg). This could be due to increase in unbound fraction of cefazolin in plasma and significant increase in cumulative 6-hr urine output (6.20 versus 3.96 ml) in OS-pretreated rats.

UR - https://www.scopus.com/pages/publications/0032697591

M3 - Article

AN - SCOPUS:0032697591

SN - 1087-1101

VL - 4

SP - 95

EP - 103

JO - Research Communications in Pharmacology and Toxicology

JF - Research Communications in Pharmacology and Toxicology

IS - 1-2

ER -

Effect of oryung-san, a Korean traditional diuretic, on the pharmacokinetics of intravenous cefazolin in rats

Abstract

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