TY - JOUR
T1 - Effect of organosulfur compounds on the expression of UDP-glucuronosyltransferase and thyroid hormone level in TCDD-treated rats
AU - Hong, Young Sook
AU - Kim, Hyung Lae
PY - 1997/12/31
Y1 - 1997/12/31
N2 - In this study, we investigated the effect of organosulfur compounds including, diallyl sulfide (DAS), garlic extract, and dially disulfide (DADS) on inducible expression of UDP-glucuronosyltransferase (UGT1) and thyroid hormone level in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. We measured UGT1 gene expression in rat liver and lung tissues after treatments. We found that a correlation was found to exist between UGT1 gene expression and active T4 concentrations. The total concentration of plasma T4 decreased in TCDD-alone treated male and female rats compared to control animals (TCDD-alone < control). Plasma T4 concentration in TCDD + DAS, TCDD + garlic extract and TCDD + DADS treated groups were moderately higher than in TCDD alone animals, but lower than control animals. TCDD + DAS, TCDD + garlic extract and TCDD + DADS moderately increased T4 glucuronidation and moderately reduced total T4. The nonthyroidal nature of thyroid hormone reduction observed in this study extends the evidence for microsomal enzyme inducers as indirect thyroid tumor promoters in rats. Furthermore, the results of present study suggest protective effects of DAS, garlic extract, or DADS on TCDD-induced changes.
AB - In this study, we investigated the effect of organosulfur compounds including, diallyl sulfide (DAS), garlic extract, and dially disulfide (DADS) on inducible expression of UDP-glucuronosyltransferase (UGT1) and thyroid hormone level in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. We measured UGT1 gene expression in rat liver and lung tissues after treatments. We found that a correlation was found to exist between UGT1 gene expression and active T4 concentrations. The total concentration of plasma T4 decreased in TCDD-alone treated male and female rats compared to control animals (TCDD-alone < control). Plasma T4 concentration in TCDD + DAS, TCDD + garlic extract and TCDD + DADS treated groups were moderately higher than in TCDD alone animals, but lower than control animals. TCDD + DAS, TCDD + garlic extract and TCDD + DADS moderately increased T4 glucuronidation and moderately reduced total T4. The nonthyroidal nature of thyroid hormone reduction observed in this study extends the evidence for microsomal enzyme inducers as indirect thyroid tumor promoters in rats. Furthermore, the results of present study suggest protective effects of DAS, garlic extract, or DADS on TCDD-induced changes.
KW - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
KW - Dially disulfide
KW - Dially sulfide
KW - Garlic extract
KW - UDP-glucuronosyltransferase
UR - http://www.scopus.com/inward/record.url?scp=0031593164&partnerID=8YFLogxK
U2 - 10.1038/emm.1997.29
DO - 10.1038/emm.1997.29
M3 - Article
AN - SCOPUS:0031593164
SN - 1226-3613
VL - 29
SP - 191
EP - 196
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 4
ER -