Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial

Soo yeon Park; Oran Kwon; Ji Yeon Kim

doi:10.1016/j.biopha.2021.112552

Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial

Soo yeon Park, Oran Kwon, Ji Yeon Kim

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Blood glucose is inadequately controlled in diabetes mellitus, causing various inflammation-related complications. This study aimed to investigate responses to an oral sucrose/lipid challenge in the context of glucose metabolism after consumption of Mori ramulus (MR) extract. In this study on healthy subjects, the optimal dose and safety of MR were confirmed in a preliminary pilot trial (n = 24), meanwhile, blood glucose, insulin, and inflammatory marker levels were detected via an oral sucrose/lipid tolerance test in the main trial (n = 36). In the main study, the blood glucose response was significantly decreased after 240 min in the MR group. Compared to the placebo group, the treatment group exhibited plasma insulin levels that were significantly increased at 120 min and decreased at 240 min. In conclusion, a single MR extract dose protects against inflammation induced by high-fat/sugar to maintain normal insulin secretion and thus helps to maintain postprandial blood glucose levels via an inflammatory mechanism.

Original language	English
Article number	112552
Journal	Biomedicine and Pharmacotherapy
Volume	146
DOIs	https://doi.org/10.1016/j.biopha.2021.112552
State	Published - Feb 2022

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (No. 2021R1A2C2009309) and Regional Innovation System (RIS) program (R0002111), Ministry of Trade, Industry and Energy, Republic of Korea. S-YP and OK conceived and designed the study; S-YP conducted research; S-YP, OK, and JYK interpreted and analyzed the data; S-YP and JYK wrote the paper; JYK had primary responsibility for final content. All authors read and approved the final manuscript.

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (No. 2021R1A2C2009309 ) and Regional Innovation System (RIS) program ( R0002111 ), Ministry of Trade, Industry and Energy , Republic of Korea.

Publisher Copyright:
© 2021

Keywords

Diabetes mellitus
Glucose metabolism
High-fat/sucrose challenge
Inflammation
Mori ramulus
Morus alba L.

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@article{d33dc0e732c742c497bb4c1223dedd61,

title = "Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial",

abstract = "Blood glucose is inadequately controlled in diabetes mellitus, causing various inflammation-related complications. This study aimed to investigate responses to an oral sucrose/lipid challenge in the context of glucose metabolism after consumption of Mori ramulus (MR) extract. In this study on healthy subjects, the optimal dose and safety of MR were confirmed in a preliminary pilot trial (n = 24), meanwhile, blood glucose, insulin, and inflammatory marker levels were detected via an oral sucrose/lipid tolerance test in the main trial (n = 36). In the main study, the blood glucose response was significantly decreased after 240 min in the MR group. Compared to the placebo group, the treatment group exhibited plasma insulin levels that were significantly increased at 120 min and decreased at 240 min. In conclusion, a single MR extract dose protects against inflammation induced by high-fat/sugar to maintain normal insulin secretion and thus helps to maintain postprandial blood glucose levels via an inflammatory mechanism.",

keywords = "Diabetes mellitus, Glucose metabolism, High-fat/sucrose challenge, Inflammation, Mori ramulus, Morus alba L.",

author = "Park, {Soo yeon} and Oran Kwon and Kim, {Ji Yeon}",

note = "Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (No. 2021R1A2C2009309) and Regional Innovation System (RIS) program (R0002111), Ministry of Trade, Industry and Energy, Republic of Korea. S-YP and OK conceived and designed the study; S-YP conducted research; S-YP, OK, and JYK interpreted and analyzed the data; S-YP and JYK wrote the paper; JYK had primary responsibility for final content. All authors read and approved the final manuscript. Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (No. 2021R1A2C2009309 ) and Regional Innovation System (RIS) program ( R0002111 ), Ministry of Trade, Industry and Energy , Republic of Korea. Publisher Copyright: {\textcopyright} 2021",

year = "2022",

month = feb,

doi = "10.1016/j.biopha.2021.112552",

language = "English",

volume = "146",

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Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial. / Park, Soo yeon; Kwon, Oran; Kim, Ji Yeon.
In: Biomedicine and Pharmacotherapy, Vol. 146, 112552, 02.2022.

Research output: Contribution to journal › Article › peer-review

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T2 - A double-blind, randomized, crossover clinical trial

AU - Park, Soo yeon

AU - Kwon, Oran

AU - Kim, Ji Yeon

N1 - Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (No. 2021R1A2C2009309) and Regional Innovation System (RIS) program (R0002111), Ministry of Trade, Industry and Energy, Republic of Korea. S-YP and OK conceived and designed the study; S-YP conducted research; S-YP, OK, and JYK interpreted and analyzed the data; S-YP and JYK wrote the paper; JYK had primary responsibility for final content. All authors read and approved the final manuscript. Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (No. 2021R1A2C2009309 ) and Regional Innovation System (RIS) program ( R0002111 ), Ministry of Trade, Industry and Energy , Republic of Korea. Publisher Copyright: © 2021

PY - 2022/2

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N2 - Blood glucose is inadequately controlled in diabetes mellitus, causing various inflammation-related complications. This study aimed to investigate responses to an oral sucrose/lipid challenge in the context of glucose metabolism after consumption of Mori ramulus (MR) extract. In this study on healthy subjects, the optimal dose and safety of MR were confirmed in a preliminary pilot trial (n = 24), meanwhile, blood glucose, insulin, and inflammatory marker levels were detected via an oral sucrose/lipid tolerance test in the main trial (n = 36). In the main study, the blood glucose response was significantly decreased after 240 min in the MR group. Compared to the placebo group, the treatment group exhibited plasma insulin levels that were significantly increased at 120 min and decreased at 240 min. In conclusion, a single MR extract dose protects against inflammation induced by high-fat/sugar to maintain normal insulin secretion and thus helps to maintain postprandial blood glucose levels via an inflammatory mechanism.

AB - Blood glucose is inadequately controlled in diabetes mellitus, causing various inflammation-related complications. This study aimed to investigate responses to an oral sucrose/lipid challenge in the context of glucose metabolism after consumption of Mori ramulus (MR) extract. In this study on healthy subjects, the optimal dose and safety of MR were confirmed in a preliminary pilot trial (n = 24), meanwhile, blood glucose, insulin, and inflammatory marker levels were detected via an oral sucrose/lipid tolerance test in the main trial (n = 36). In the main study, the blood glucose response was significantly decreased after 240 min in the MR group. Compared to the placebo group, the treatment group exhibited plasma insulin levels that were significantly increased at 120 min and decreased at 240 min. In conclusion, a single MR extract dose protects against inflammation induced by high-fat/sugar to maintain normal insulin secretion and thus helps to maintain postprandial blood glucose levels via an inflammatory mechanism.

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KW - Morus alba L.

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