Abstract
Blood glucose is inadequately controlled in diabetes mellitus, causing various inflammation-related complications. This study aimed to investigate responses to an oral sucrose/lipid challenge in the context of glucose metabolism after consumption of Mori ramulus (MR) extract. In this study on healthy subjects, the optimal dose and safety of MR were confirmed in a preliminary pilot trial (n = 24), meanwhile, blood glucose, insulin, and inflammatory marker levels were detected via an oral sucrose/lipid tolerance test in the main trial (n = 36). In the main study, the blood glucose response was significantly decreased after 240 min in the MR group. Compared to the placebo group, the treatment group exhibited plasma insulin levels that were significantly increased at 120 min and decreased at 240 min. In conclusion, a single MR extract dose protects against inflammation induced by high-fat/sugar to maintain normal insulin secretion and thus helps to maintain postprandial blood glucose levels via an inflammatory mechanism.
Original language | English |
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Article number | 112552 |
Journal | Biomedicine and Pharmacotherapy |
Volume | 146 |
DOIs | |
State | Published - Feb 2022 |
Bibliographical note
Funding Information:This research was supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (No. 2021R1A2C2009309) and Regional Innovation System (RIS) program (R0002111), Ministry of Trade, Industry and Energy, Republic of Korea. S-YP and OK conceived and designed the study; S-YP conducted research; S-YP, OK, and JYK interpreted and analyzed the data; S-YP and JYK wrote the paper; JYK had primary responsibility for final content. All authors read and approved the final manuscript.
Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant funded by Ministry of Science and ICT (No. 2021R1A2C2009309 ) and Regional Innovation System (RIS) program ( R0002111 ), Ministry of Trade, Industry and Energy , Republic of Korea.
Publisher Copyright:
© 2021
Keywords
- Diabetes mellitus
- Glucose metabolism
- High-fat/sucrose challenge
- Inflammation
- Mori ramulus
- Morus alba L.