Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease: Data from the 2007-2012 KNHANES

Sojung Park, Seo Woo Kim, Chin Kook Rhee, Kyungjoo Kim, Woo Jin Kim, Kwang Ha Yoo, Chang Youl Lee, Deog Kyeom Kim, Yong Bum Park, Ki Suck Jung, Jin Hwa Lee

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Background: Several researchers have reported that the amount of protein intake is associated with lung function and airflow obstruction. However, few studies have investigated the effect of low protein intake on acute exacerbations of chronic obstructive pulmonary disease. This study aimed to investigate the effect of low protein intake on exacerbations in mild to moderate chronic obstructive pulmonary disease. Methods: We used data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2007 and 2012, linked to the National Health Insurance claims data. The clinical outcomes and the rate of exacerbation were retrospectively compared between the low protein intake group and the non-low protein intake group which was stratified by quartile categories of protein intake in 2,069 patients with mild to moderate chronic obstructive pulmonary disease. Results: The low protein intake group was significantly associated with older age, women, never smoker, low household income, and low education level, compared with the non-low protein intake group. The low protein intake group was significantly associated with increased hospitalization (18.0% vs. 10.5%, P<0.001) and emergency department utilization (1.6±1.0 vs. 1.1±0.4, P=0.033) compared with the non-low protein intake group. In multivariate analysis, the low protein intake group was associated with hospitalization (odds ratio 1.46; 95% CI, 1.09-1.96; P=0.012). The multiple linear regression analysis revealed that the amount of protein intake was associated with FVC % predicted (β=0.048, P<0.001) and FEV1 % predicted (β=0.022, P=0.015). Conclusions: Low protein intake was associated with an increased risk of exacerbations in mild to moderate chronic obstructive pulmonary disease. The data are available at the KNHANES website (https://knhanes.cdc.go.kr).

Original languageEnglish
Pages (from-to)5592-5603
Number of pages12
JournalJournal of Thoracic Disease
Volume13
Issue number10
DOIs
StatePublished - Oct 2021

Bibliographical note

Funding Information:
Funding: This work was supported by the National Research Foundation of Korea (NRF-2020R1A5A2019210). The funding source had no role in design of the study, in data collection, analysis, or interpretation, and no role in writing the report or in the decision to submit the paper for publication.

Funding Information:
Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at https://dx.doi. org/10.21037/jtd-20-3433 Data Sharing Statement: Available at https://dx.doi. org/10.21037/jtd-20-3433 Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi. org/10.21037/jtd-20-3433). Chin Kook Rhee and Ki-Suck Jung serve as unpaid editorial board members of Journal of Thoracic Disease. All authors report funding from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-0027945). The funding source had no role in design of the study, in data collection, analysis, or interpretation, and no role in writing the report or in the decision to submit the paper for publication.

Publisher Copyright:
© Journal of Thoracic Disease. All rights reserved.

Keywords

  • Chronic obstructive pulmonary disease (COPD)
  • Exacerbation
  • Nutrient
  • Protein
  • Pulmonary function

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