Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease: Data from the 2007-2012 KNHANES

Sojung Park; Seo Woo Kim; Chin Kook Rhee; Kyungjoo Kim; Woo Jin Kim; Kwang Ha Yoo; Chang Youl Lee; Deog Kyeom Kim; Yong Bum Park; Ki Suck Jung; Jin Hwa Lee

doi:10.21037/jtd-20-3433

Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease: Data from the 2007-2012 KNHANES

Sojung Park, Seo Woo Kim, Chin Kook Rhee, Kyungjoo Kim, Woo Jin Kim, Kwang Ha Yoo, Chang Youl Lee, Deog Kyeom Kim, Yong Bum Park, Ki Suck Jung, Jin Hwa Lee

Department of Internal Medicine

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Background: Several researchers have reported that the amount of protein intake is associated with lung function and airflow obstruction. However, few studies have investigated the effect of low protein intake on acute exacerbations of chronic obstructive pulmonary disease. This study aimed to investigate the effect of low protein intake on exacerbations in mild to moderate chronic obstructive pulmonary disease. Methods: We used data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2007 and 2012, linked to the National Health Insurance claims data. The clinical outcomes and the rate of exacerbation were retrospectively compared between the low protein intake group and the non-low protein intake group which was stratified by quartile categories of protein intake in 2,069 patients with mild to moderate chronic obstructive pulmonary disease. Results: The low protein intake group was significantly associated with older age, women, never smoker, low household income, and low education level, compared with the non-low protein intake group. The low protein intake group was significantly associated with increased hospitalization (18.0% vs. 10.5%, P<0.001) and emergency department utilization (1.6±1.0 vs. 1.1±0.4, P=0.033) compared with the non-low protein intake group. In multivariate analysis, the low protein intake group was associated with hospitalization (odds ratio 1.46; 95% CI, 1.09-1.96; P=0.012). The multiple linear regression analysis revealed that the amount of protein intake was associated with FVC % predicted (β=0.048, P<0.001) and FEV₁ % predicted (β=0.022, P=0.015). Conclusions: Low protein intake was associated with an increased risk of exacerbations in mild to moderate chronic obstructive pulmonary disease. The data are available at the KNHANES website (https://knhanes.cdc.go.kr).

Original language	English
Pages (from-to)	5592-5603
Number of pages	12
Journal	Journal of Thoracic Disease
Volume	13
Issue number	10
DOIs	https://doi.org/10.21037/jtd-20-3433
State	Published - Oct 2021

Bibliographical note

Funding Information:
Funding: This work was supported by the National Research Foundation of Korea (NRF-2020R1A5A2019210). The funding source had no role in design of the study, in data collection, analysis, or interpretation, and no role in writing the report or in the decision to submit the paper for publication.

Funding Information:
Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at https://dx.doi. org/10.21037/jtd-20-3433 Data Sharing Statement: Available at https://dx.doi. org/10.21037/jtd-20-3433 Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi. org/10.21037/jtd-20-3433). Chin Kook Rhee and Ki-Suck Jung serve as unpaid editorial board members of Journal of Thoracic Disease. All authors report funding from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-0027945). The funding source had no role in design of the study, in data collection, analysis, or interpretation, and no role in writing the report or in the decision to submit the paper for publication.

Publisher Copyright:
© Journal of Thoracic Disease. All rights reserved.

Keywords

Chronic obstructive pulmonary disease (COPD)
Exacerbation
Nutrient
Protein
Pulmonary function

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10.21037/jtd-20-3433

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@article{71643118841c4cb8af1b57e2bcee0e46,

title = "Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease: Data from the 2007-2012 KNHANES",

abstract = "Background: Several researchers have reported that the amount of protein intake is associated with lung function and airflow obstruction. However, few studies have investigated the effect of low protein intake on acute exacerbations of chronic obstructive pulmonary disease. This study aimed to investigate the effect of low protein intake on exacerbations in mild to moderate chronic obstructive pulmonary disease. Methods: We used data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2007 and 2012, linked to the National Health Insurance claims data. The clinical outcomes and the rate of exacerbation were retrospectively compared between the low protein intake group and the non-low protein intake group which was stratified by quartile categories of protein intake in 2,069 patients with mild to moderate chronic obstructive pulmonary disease. Results: The low protein intake group was significantly associated with older age, women, never smoker, low household income, and low education level, compared with the non-low protein intake group. The low protein intake group was significantly associated with increased hospitalization (18.0% vs. 10.5%, P<0.001) and emergency department utilization (1.6±1.0 vs. 1.1±0.4, P=0.033) compared with the non-low protein intake group. In multivariate analysis, the low protein intake group was associated with hospitalization (odds ratio 1.46; 95% CI, 1.09-1.96; P=0.012). The multiple linear regression analysis revealed that the amount of protein intake was associated with FVC % predicted (β=0.048, P<0.001) and FEV1 % predicted (β=0.022, P=0.015). Conclusions: Low protein intake was associated with an increased risk of exacerbations in mild to moderate chronic obstructive pulmonary disease. The data are available at the KNHANES website (https://knhanes.cdc.go.kr).",

keywords = "Chronic obstructive pulmonary disease (COPD), Exacerbation, Nutrient, Protein, Pulmonary function",

author = "Sojung Park and Kim, {Seo Woo} and Rhee, {Chin Kook} and Kyungjoo Kim and Kim, {Woo Jin} and Yoo, {Kwang Ha} and Lee, {Chang Youl} and Kim, {Deog Kyeom} and Park, {Yong Bum} and Jung, {Ki Suck} and Lee, {Jin Hwa}",

note = "Funding Information: Funding: This work was supported by the National Research Foundation of Korea (NRF-2020R1A5A2019210). The funding source had no role in design of the study, in data collection, analysis, or interpretation, and no role in writing the report or in the decision to submit the paper for publication. Funding Information: Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at https://dx.doi. org/10.21037/jtd-20-3433 Data Sharing Statement: Available at https://dx.doi. org/10.21037/jtd-20-3433 Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi. org/10.21037/jtd-20-3433). Chin Kook Rhee and Ki-Suck Jung serve as unpaid editorial board members of Journal of Thoracic Disease. All authors report funding from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-0027945). The funding source had no role in design of the study, in data collection, analysis, or interpretation, and no role in writing the report or in the decision to submit the paper for publication. Publisher Copyright: {\textcopyright} Journal of Thoracic Disease. All rights reserved.",

year = "2021",

month = oct,

doi = "10.21037/jtd-20-3433",

language = "English",

volume = "13",

pages = "5592--5603",

journal = "Journal of Thoracic Disease",

issn = "2072-1439",

publisher = "Pioneer Bioscience Publishing Company (PBPC)",

number = "10",

}

TY - JOUR

T1 - Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease

T2 - Data from the 2007-2012 KNHANES

AU - Park, Sojung

AU - Kim, Seo Woo

AU - Rhee, Chin Kook

AU - Kim, Kyungjoo

AU - Kim, Woo Jin

AU - Yoo, Kwang Ha

AU - Lee, Chang Youl

AU - Kim, Deog Kyeom

AU - Park, Yong Bum

AU - Jung, Ki Suck

AU - Lee, Jin Hwa

N1 - Funding Information: Funding: This work was supported by the National Research Foundation of Korea (NRF-2020R1A5A2019210). The funding source had no role in design of the study, in data collection, analysis, or interpretation, and no role in writing the report or in the decision to submit the paper for publication. Funding Information: Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at https://dx.doi. org/10.21037/jtd-20-3433 Data Sharing Statement: Available at https://dx.doi. org/10.21037/jtd-20-3433 Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi. org/10.21037/jtd-20-3433). Chin Kook Rhee and Ki-Suck Jung serve as unpaid editorial board members of Journal of Thoracic Disease. All authors report funding from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-0027945). The funding source had no role in design of the study, in data collection, analysis, or interpretation, and no role in writing the report or in the decision to submit the paper for publication. Publisher Copyright: © Journal of Thoracic Disease. All rights reserved.

PY - 2021/10

Y1 - 2021/10

N2 - Background: Several researchers have reported that the amount of protein intake is associated with lung function and airflow obstruction. However, few studies have investigated the effect of low protein intake on acute exacerbations of chronic obstructive pulmonary disease. This study aimed to investigate the effect of low protein intake on exacerbations in mild to moderate chronic obstructive pulmonary disease. Methods: We used data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2007 and 2012, linked to the National Health Insurance claims data. The clinical outcomes and the rate of exacerbation were retrospectively compared between the low protein intake group and the non-low protein intake group which was stratified by quartile categories of protein intake in 2,069 patients with mild to moderate chronic obstructive pulmonary disease. Results: The low protein intake group was significantly associated with older age, women, never smoker, low household income, and low education level, compared with the non-low protein intake group. The low protein intake group was significantly associated with increased hospitalization (18.0% vs. 10.5%, P<0.001) and emergency department utilization (1.6±1.0 vs. 1.1±0.4, P=0.033) compared with the non-low protein intake group. In multivariate analysis, the low protein intake group was associated with hospitalization (odds ratio 1.46; 95% CI, 1.09-1.96; P=0.012). The multiple linear regression analysis revealed that the amount of protein intake was associated with FVC % predicted (β=0.048, P<0.001) and FEV1 % predicted (β=0.022, P=0.015). Conclusions: Low protein intake was associated with an increased risk of exacerbations in mild to moderate chronic obstructive pulmonary disease. The data are available at the KNHANES website (https://knhanes.cdc.go.kr).

AB - Background: Several researchers have reported that the amount of protein intake is associated with lung function and airflow obstruction. However, few studies have investigated the effect of low protein intake on acute exacerbations of chronic obstructive pulmonary disease. This study aimed to investigate the effect of low protein intake on exacerbations in mild to moderate chronic obstructive pulmonary disease. Methods: We used data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2007 and 2012, linked to the National Health Insurance claims data. The clinical outcomes and the rate of exacerbation were retrospectively compared between the low protein intake group and the non-low protein intake group which was stratified by quartile categories of protein intake in 2,069 patients with mild to moderate chronic obstructive pulmonary disease. Results: The low protein intake group was significantly associated with older age, women, never smoker, low household income, and low education level, compared with the non-low protein intake group. The low protein intake group was significantly associated with increased hospitalization (18.0% vs. 10.5%, P<0.001) and emergency department utilization (1.6±1.0 vs. 1.1±0.4, P=0.033) compared with the non-low protein intake group. In multivariate analysis, the low protein intake group was associated with hospitalization (odds ratio 1.46; 95% CI, 1.09-1.96; P=0.012). The multiple linear regression analysis revealed that the amount of protein intake was associated with FVC % predicted (β=0.048, P<0.001) and FEV1 % predicted (β=0.022, P=0.015). Conclusions: Low protein intake was associated with an increased risk of exacerbations in mild to moderate chronic obstructive pulmonary disease. The data are available at the KNHANES website (https://knhanes.cdc.go.kr).

KW - Chronic obstructive pulmonary disease (COPD)

KW - Exacerbation

KW - Nutrient

KW - Protein

KW - Pulmonary function

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U2 - 10.21037/jtd-20-3433

DO - 10.21037/jtd-20-3433

M3 - Review article

AN - SCOPUS:85118485652

SN - 2072-1439

VL - 13

SP - 5592

EP - 5603

JO - Journal of Thoracic Disease

JF - Journal of Thoracic Disease

IS - 10

ER -

Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease: Data from the 2007-2012 KNHANES

Abstract

Bibliographical note

Keywords

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