Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver

Sun Young Ju, Kyung Ah Cho, Su Jin Cho, Yun Jae Jung, So Youn Woo, Ju Young Seoh, Ho Seong Han, Kyung Ha Ryu

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6 Scopus citations


Restricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24 h. After hypoxic treatment, BMCs of apoptotic fraction were decreased. The expression of CXCR4 was noticeably increased in the hypoxia-treated BMCs and their migration in response to SDF-1α was enhanced compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher degree of engraftment to the CCl4-injured liver than the normoxic cells. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF-1α, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl4 damaged liver.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalCell Biology International
Issue number1
StatePublished - Jan 2009

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Research Foundation (KRF-2003-041-E00136).


  • Bone marrow cells
  • Cell migration
  • Hypoxia
  • SDF-1


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