@article{bb475e2c054f485b8f08ac1fe6ab2da9,
title = "Effect of Ecklonia cava polyphenol on adiposity reduction is associated with gut microbiota composition in subjects with abdominal obesity: A secondary analysis",
abstract = "A previous randomized controlled trial showed that Ecklonia cava polyphenol (EP) has the potential to reduce fat accumulation based on clinical outcomes and target gene expression analysis. Here, we investigated whether EP affects gut microbiota composition and impacts clinical outcomes. To this end, we analyzed 16S rRNA sequencing on fecal samples from subgroup subjects with abdominal obesity (n = 20/group). Compared with the placebo treatment, EP supplementation attenuated the increase of the Firmicutes-to-Bacteroidetes ratio and changed 18 genera composition, including genera related to obesity and fermentation of unabsorbed compounds. Furthermore, Spearman's correlation and Tax4Fun analysis demonstrated that alterations in genera are tightly associated with reducing adiposity via regulating oxidative stress. Together, these findings suggest that the gut microbiota-regulating effect might be a possible mechanism of EP-induced adiposity reduction in subjects with abdominal obesity.",
keywords = "Association, Functional profile prediction, Gut microbiota, Human clinical trial, Obesity, Phlorotannin",
author = "Lee, {Yu Sim} and Seunghee Kang and Nayeon Kang and Jaehong Yu and Taesung Park and Sunjae Lee and Oran Kwon",
note = "Funding Information: This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF), funded by the Korea Ministry of Science & ICT (grant numbers: 2012M3A9C4048761 and 2013M3A9C4078158). Funding Information: We are thankful to all the study participants for the substantial time and effort they spent in contributing to our study. We also thank Botamedi, Inc. (Korea) for processing and providing the test materials used in both two groups. This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF), funded by the Korea Ministry of Science & ICT (grant numbers: 2012M3A9C4048761 and 2013M3A9C4078158). Mendeley data: SeaPN_BM (DOI: 10.17632/cfwj5hxb3r.1) Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = dec,
doi = "10.1016/j.jff.2022.105333",
language = "English",
volume = "99",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Ltd.",
}
