Effect of dopamine on a voltage-gated potassium channel in a jellyfish motor neuron

Jun Mo Chung, Andrew N. Spencer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


To swimming motor neurons (SMNs) of Polyorchis penicillatus, a hydrozoan medusae, dopamine (DA) acts as an inhibitory neurotransmitter by hyperpolarizing its membrane potential and decreasing its firing rate as well. Such an inhibitory action of DA is caused by an increased permeability to potassium (K) ions. To investigate whether voltage-gated K channels are directly responsible for the membrane hyperpolarization induced by DA, we employed whole-cell voltage clamp configuration. One μM DA applied to SMNs increased the peak and rear values of voltage-gated K currents by 37 and 54%, respectively, in a reversible manner. Combined with subtraction analysis, this result suggests that the outflux of K ions by DA in SMNs occurs mainly through rectifier-like K channels.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalJournal of Biochemistry and Molecular Biology
Issue number2
StatePublished - 1996


  • Catecholamines
  • Cnidaria
  • K rectifier
  • Voltage-sensitive potassium channel
  • Whole-cell voltage clamp


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