Effect of donor-specific antibodies and panel reactive antibodies in living donor liver transplant recipients

Seung Hwan Song, Myoung Soo Kim, Jung Jun Lee, Man Ki Ju, Jae Geun Lee, Juhan Lee, Jin Sub Choi, Gi Hong Choi, Soon Il Kim, Dong Jin Joo

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10 Scopus citations


Purpose: Preformed circulating donor-specific antibodies (DSAs) immunologically challenge vascular endothelium and the bile duct. However, the liver is an immune-tolerant organ and can avoid immunological challenges. This study was undertaken to analyze the effects of DSAs after adult living donor liver transplantation (LDLT). Methods: We retrospectively reviewed 219 LDLT patients' records treated at our center. Results: Of the 219 patients, 32 (14.6%) were DSA (+) and 187 (85.4%) were DSA (-). Class I DSAs were present in 18 patients, class II in seven patients, and both in seven patients. Seven patients (3.2%) showed DSA to HLA-A, four (1.8%) to HLA-B, seven (3.2%) to HLA-DR, and 14 (6.4%) to two or more HLAs. More DSAs were observed in female recipients than male recipients in the DSA (+) group. The DSA (+) group showed significantly higher levels of class I and II panel reactive antibody (PRA) than did the DSA (-) group. No significant intergroup differences were found between incidences of primary nonfunction, acute rejection, vascular complication, or biliary complication. There were no significant differences in graft survival rates between the two groups. However, the recipients with multiple DSAs tended to have more acute rejection episodes and events of biliary stricture and lower graft survival rates than did patients in the DSA (-) group. Conclusion: In LDLT, the presence of multiple DSAs and high PRA seemed to be associated with poor graft outcomes, although our results did not reach statistical significance. Large cohort studies are necessary to clarify the impact of DSA and PRA in LDLT.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalAnnals of Surgical Treatment and Research
Issue number2
StatePublished - 1 Feb 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015, the Korean Surgical Society.


  • Acute rejection
  • Donor specific antibody
  • Graft survival
  • Liver transplantation
  • Sensitization


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