Effect of compound K, a metabolite of ginseng saponin, combined with γ-ray radiation in human lung cancer cells in vitro and in vivo

Sungwook Chae, Kyoung Ah Kang, Weon Young Chang, Min Jung Kim, Su Jae Lee, Yun Sil Lee, Hee Sun Kim, Dong Hyun Kim, Jin Won Hyun

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

Pretreatment of NCI-H460 human lung cancer cells with compound K produced by intestinal bacteria enhances γ-ray radiation-induced cell death. Increases in apoptosis induced by combined treatment are made apparent in the observation of nuclear fragmentation, loss of mitochondrial membrane potential (Δ ψ), and activation of caspase 3. Apoptosis induced by compound K and γ-ray radiation is associated with reactive oxygen species (ROS) generation. Furthermore, compound K, in combination with γ-ray radiation, has an enhanced effect in the regression of NCI-H460 tumor xenografts of nude mice. These results suggest that compound K has possible application for cancer therapy when used in combination with γ-ray radiation.

Original languageEnglish
Pages (from-to)5777-5782
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number13
DOIs
StatePublished - 8 Jul 2009

Keywords

  • Apoptosis
  • Cancer therapy
  • Compound K
  • Radiation
  • ROS
  • Tumor xenograft

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