Kitosan kaplı ipliklerin anastomoz gücü arttırma üzerine etkisi

Translated title of the contribution: Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis

Yüksel Altınel, Soon Soup Chung, Güven Okay, Nesrin Uğraş, Ahmet Fatih Işık, Ersin Öztürk, Halil Özgüç

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

BACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healing effect. METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan was applied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl, PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7 th and 14 th days, eight rats from each group were euthanized. RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl–chitosan was lower than PDS–chitosan on the 14th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coated Vicryl were lower than Vicryl and chitosan-coated PDS on the 14 th day (p<0.05). The tensile strength of Vicryl–chitosan increased more than Vicryl in vitro (p<0.05) on the 14 th and 7 th days, but there was no difference in vivo. The tensile strength of PDS–chitosan decreased more than PDS on the 7 th day in vivo (p<0.05). CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro and PDS in vivo was slightly improved.

Translated title of the contributionEffect of chitosan coating on surgical sutures to strengthen the colonic anastomosis
Original languageTurkish
Pages (from-to)405-411
Number of pages7
JournalUlusal Travma ve Acil Cerrahi Dergisi
Volume24
Issue number5
DOIs
StatePublished - 2018

Keywords

  • Anastomosis
  • Chitosan
  • PDS suture
  • Tensile strength
  • Vicryl suture
  • Wound healing

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