To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.
|Number of pages||11|
|Journal||International Journal of Biological Macromolecules|
|State||Published - 1 May 2008|
Bibliographical noteFunding Information:
This work was supported by a grant from the Korean Science and Engineering Foundation through the Intellectual Biointerface Engineering Center at Seoul National University and by a grant from the Korean Ministry of Commerce, Industry, and Energy.
- Human epidermal keratinocytes
- Nanofibrous scaffolds