Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes

Choung Ryong Yoo, In Sung Yeo, Ko Eun Park, Ji Hun Park, Seung Jin Lee, Won Ho Park, Byung Moo Min

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.

Original languageEnglish
Pages (from-to)324-334
Number of pages11
JournalInternational Journal of Biological Macromolecules
Volume42
Issue number4
DOIs
StatePublished - 1 May 2008

Keywords

  • Electrospinning
  • Human epidermal keratinocytes
  • Nanofibrous scaffolds

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