Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes

Choung Ryong Yoo; In Sung Yeo; Ko Eun Park; Ji Hun Park; Seung Jin Lee; Won Ho Park; Byung Moo Min

doi:10.1016/j.ijbiomac.2007.12.004

Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes

Choung Ryong Yoo, In Sung Yeo, Ko Eun Park, Ji Hun Park, Seung Jin Lee, Won Ho Park, Byung Moo Min

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.

Original language	English
Pages (from-to)	324-334
Number of pages	11
Journal	International Journal of Biological Macromolecules
Volume	42
Issue number	4
DOIs	https://doi.org/10.1016/j.ijbiomac.2007.12.004
State	Published - 1 May 2008

Bibliographical note

Funding Information:
This work was supported by a grant from the Korean Science and Engineering Foundation through the Intellectual Biointerface Engineering Center at Seoul National University and by a grant from the Korean Ministry of Commerce, Industry, and Energy.

Keywords

Electrospinning
Human epidermal keratinocytes
Nanofibrous scaffolds

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10.1016/j.ijbiomac.2007.12.004

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title = "Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes",

abstract = "To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.",

keywords = "Electrospinning, Human epidermal keratinocytes, Nanofibrous scaffolds",

author = "Yoo, {Choung Ryong} and Yeo, {In Sung} and Park, {Ko Eun} and Park, {Ji Hun} and Lee, {Seung Jin} and Park, {Won Ho} and Min, {Byung Moo}",

note = "Funding Information: This work was supported by a grant from the Korean Science and Engineering Foundation through the Intellectual Biointerface Engineering Center at Seoul National University and by a grant from the Korean Ministry of Commerce, Industry, and Energy.",

year = "2008",

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doi = "10.1016/j.ijbiomac.2007.12.004",

language = "English",

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AU - Yoo, Choung Ryong

AU - Yeo, In Sung

AU - Park, Ko Eun

AU - Park, Ji Hun

AU - Lee, Seung Jin

AU - Park, Won Ho

AU - Min, Byung Moo

N1 - Funding Information: This work was supported by a grant from the Korean Science and Engineering Foundation through the Intellectual Biointerface Engineering Center at Seoul National University and by a grant from the Korean Ministry of Commerce, Industry, and Energy.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.

AB - To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.

KW - Electrospinning

KW - Human epidermal keratinocytes

KW - Nanofibrous scaffolds

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JF - International Journal of Biological Macromolecules

IS - 4

ER -

Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes

Abstract

Bibliographical note

Keywords

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