TY - JOUR
T1 - Effect of biocompatible peritoneal dialysis solution on residual renal function
T2 - A systematic review of randomized controlled trials
AU - Seo, Eun Young
AU - An, Sook Hee
AU - Cho, Jang Hee
AU - Suh, Hae Sun
AU - Park, Sun Hee
AU - Gwak, Hyesun
AU - Kim, Yong Lim
AU - Ha, Hunjoo
N1 - Publisher Copyright:
© 2014 International Society for Peritoneal Dialysis.
PY - 2014
Y1 - 2014
N2 - Introduction: Residual renal function (RRF) plays an important role in outcome of peritoneal dialysis (PD) including mortality. It is, therefore, important to provide a strategy for the preservation of RRF. The objective of this study was to evaluate relative protective effects of new glucose-based multicompartmental PD solution (PDS), which is well known to be more biocompatible than glucose-based conventional PDS, on RRF compared to conventional PDS by performing a systematic review (SR) of randomized controlled trials. Methods: We searched studies presented up to January 2014 in MEDLINE, EMBASE, the COCHRANE library, and local databases. Three independent reviewers reviewed and extracted prespecified data from each study. The random effects model, a more conservative analysis model, was used to combine trials and to perform stratified analyses based on the duration of follow-up. Study quality was assessed using the Cochrane Handbook for risk of bias. Eleven articles with 1,034 patients were identified for the SR. Results: The heterogeneity of the studies under 12 months was very high, and the heterogeneity decreased substantially when we stratified studies by the duration of follow-up. The mean difference of the studies after 12 months was 0.46 mL/min/1.73 m2 (95% confidence interval = 0.25 to + 0.67). Conclusion: New PDS showed the effect to preserve and improve RRF for long-term use compared to conventional PDS, even though it did not show a significant difference to preserve RRF for short-term use.
AB - Introduction: Residual renal function (RRF) plays an important role in outcome of peritoneal dialysis (PD) including mortality. It is, therefore, important to provide a strategy for the preservation of RRF. The objective of this study was to evaluate relative protective effects of new glucose-based multicompartmental PD solution (PDS), which is well known to be more biocompatible than glucose-based conventional PDS, on RRF compared to conventional PDS by performing a systematic review (SR) of randomized controlled trials. Methods: We searched studies presented up to January 2014 in MEDLINE, EMBASE, the COCHRANE library, and local databases. Three independent reviewers reviewed and extracted prespecified data from each study. The random effects model, a more conservative analysis model, was used to combine trials and to perform stratified analyses based on the duration of follow-up. Study quality was assessed using the Cochrane Handbook for risk of bias. Eleven articles with 1,034 patients were identified for the SR. Results: The heterogeneity of the studies under 12 months was very high, and the heterogeneity decreased substantially when we stratified studies by the duration of follow-up. The mean difference of the studies after 12 months was 0.46 mL/min/1.73 m2 (95% confidence interval = 0.25 to + 0.67). Conclusion: New PDS showed the effect to preserve and improve RRF for long-term use compared to conventional PDS, even though it did not show a significant difference to preserve RRF for short-term use.
KW - Peritoneal dialysis solutions
KW - Randomized controlled trials
KW - Residual renal function
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=84928237787&partnerID=8YFLogxK
U2 - 10.3747/pdi.2012.00331
DO - 10.3747/pdi.2012.00331
M3 - Article
C2 - 25185015
AN - SCOPUS:84928237787
SN - 0896-8608
VL - 34
SP - 724
EP - 731
JO - Peritoneal Dialysis International
JF - Peritoneal Dialysis International
IS - 7
ER -