Effect of an aqueous extract of dried immature fruit of Poncirus trifoliata (L.) Raf. on intestinal transit in rodents with experimental gastrointestinal motility dysfunctions

Hyun Tai Lee, Eun Kyoung Seo, Suk Jae Chung, Chang Koo Shim

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The effect of an aqueous extract of the dried immature fruit of Poncirus trifoliata Raf. (Rutaceae) (PF-W) on gastrointestinal (GI) motor function was investigated by measuring the intestinal transit rate (ITR) of Evans blue in rats and mice with experimental GI motility dysfunctions (GMDs). GMD was induced by appropriate surgery or by the administration of acetic acid, atropine, L-DOPA, or morphine to the animals. The ITR in these GMD animals was significantly retarded compared to normal animals. The retardation, however, was significantly inhibited by the intragastric administration of PF-W (0.1-1 g/kg) in a dose dependent manner for all GMD models except for L-DOPA-induced GMD. The above results suggest that PF-W has the potential for development as a prokinetic agent that may prevent or alleviate GMD in human patients.

Original languageEnglish
Pages (from-to)302-306
Number of pages5
JournalJournal of Ethnopharmacology
Volume102
Issue number2
DOIs
StatePublished - 14 Nov 2005

Keywords

  • Cisapride
  • Evans blue
  • Gastrointestinal motility dysfunction
  • Ileus
  • Intestinal transit
  • Poncirus trifoliata (L.) Raf. (Rutaceae)

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