Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells

Xiang Shu Xian; Hyeyeon Park; Yu Kyung Cho; In Seok Lee; Sang Woo Kim; Myung Gyu Choi; In Sik Chung; Ki Hwan Han; Jae Myung Park

doi:10.1002/jcb.22540

Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells

Xiang Shu Xian, Hyeyeon Park, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung Gyu Choi, In Sik Chung, Ki Hwan Han, Jae Myung Park

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB₁ receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy.

Original language	English
Pages (from-to)	321-332
Number of pages	12
Journal	Journal of Cellular Biochemistry
Volume	110
Issue number	2
DOIs	https://doi.org/10.1002/jcb.22540
State	Published - 15 May 2010

Keywords

Apoptosis
Cannabinoid
Gastric cancer
Invasion
Proliferation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jcb.22540

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title = "Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells",

abstract = "Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB1 receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy.",

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author = "Xian, {Xiang Shu} and Hyeyeon Park and Cho, {Yu Kyung} and Lee, {In Seok} and Kim, {Sang Woo} and Choi, {Myung Gyu} and Chung, {In Sik} and Han, {Ki Hwan} and Park, {Jae Myung}",

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AU - Xian, Xiang Shu

AU - Park, Hyeyeon

AU - Cho, Yu Kyung

AU - Lee, In Seok

AU - Kim, Sang Woo

AU - Choi, Myung Gyu

AU - Chung, In Sik

AU - Han, Ki Hwan

AU - Park, Jae Myung

PY - 2010/5/15

Y1 - 2010/5/15

N2 - Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB1 receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy.

AB - Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB1 receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy.

KW - Apoptosis

KW - Cannabinoid

KW - Gastric cancer

KW - Invasion

KW - Proliferation

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ER -

Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells

Abstract

Keywords

UN SDGs

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