Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells

Xiang Shu Xian, Hyeyeon Park, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung Gyu Choi, In Sik Chung, Ki Hwan Han, Jae Myung Park

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB1 receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy.

Original languageEnglish
Pages (from-to)321-332
Number of pages12
JournalJournal of Cellular Biochemistry
Volume110
Issue number2
DOIs
StatePublished - 15 May 2010

Keywords

  • Apoptosis
  • Cannabinoid
  • Gastric cancer
  • Invasion
  • Proliferation

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