Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Jinse Park; Si Eun Kim; Eun Joo Kim; Byung In Lee; Jee Hyang Jeong; Hae Ri Na; Seong Hye Choi; Do Young Kang; Kyung Won Park

doi:10.2147/CIA.S200269

Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Jinse Park, Si Eun Kim, Eun Joo Kim, Byung In Lee, Jee Hyang Jeong, Hae Ri Na, Seong Hye Choi, Do Young Kang, Kyung Won Park

Department of Neurology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

Original language	English
Pages (from-to)	1167-1175
Number of pages	9
Journal	Clinical Interventions in Aging
Volume	14
DOIs	https://doi.org/10.2147/CIA.S200269
State	Published - 2019

Bibliographical note

Publisher Copyright:
© 2019 Park et al.

Keywords

Brain PET
Cognitive training
Mild cognitive impairment

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10.2147/CIA.S200269

Cite this

@article{aff5f71cf28145d898aebcc031045691,

title = "Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment",

abstract = "Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.",

keywords = "Brain PET, Cognitive training, Mild cognitive impairment",

author = "Jinse Park and Kim, \{Si Eun\} and Kim, \{Eun Joo\} and Lee, \{Byung In\} and Jeong, \{Jee Hyang\} and Na, \{Hae Ri\} and Choi, \{Seong Hye\} and Kang, \{Do Young\} and Park, \{Kyung Won\}",

note = "Publisher Copyright: {\textcopyright} 2019 Park et al.",

year = "2019",

doi = "10.2147/CIA.S200269",

language = "English",

volume = "14",

pages = "1167--1175",

journal = "Clinical Interventions in Aging",

issn = "1176-9092",

publisher = "Dove Medical Press Ltd",

}

TY - JOUR

T1 - Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

AU - Park, Jinse

AU - Kim, Si Eun

AU - Kim, Eun Joo

AU - Lee, Byung In

AU - Jeong, Jee Hyang

AU - Na, Hae Ri

AU - Choi, Seong Hye

AU - Kang, Do Young

AU - Park, Kyung Won

PY - 2019

Y1 - 2019

N2 - Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

AB - Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

KW - Brain PET

KW - Cognitive training

KW - Mild cognitive impairment

UR - https://www.scopus.com/pages/publications/85069709290

U2 - 10.2147/CIA.S200269

DO - 10.2147/CIA.S200269

M3 - Article

C2 - 31303750

AN - SCOPUS:85069709290

SN - 1176-9092

VL - 14

SP - 1167

EP - 1175

JO - Clinical Interventions in Aging

JF - Clinical Interventions in Aging

ER -

Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Abstract

Bibliographical note

Keywords

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Cite this