Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Jinse Park; Si Eun Kim; Eun Joo Kim; Byung In Lee; Jee Hyang Jeong; Hae Ri Na; Seong Hye Choi; Do Young Kang; Kyung Won Park

doi:10.2147/CIA.S200269

Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Jinse Park
, Si Eun Kim
, Eun Joo Kim
, Byung In Lee
, Jee Hyang Jeong
, Hae Ri Na
, Seong Hye Choi
, Do Young Kang
, Kyung Won Park

Department of Neurology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

Original language	English
Pages (from-to)	1167-1175
Number of pages	9
Journal	Clinical Interventions in Aging
Volume	14
DOIs	https://doi.org/10.2147/CIA.S200269
State	Published - 2019

Bibliographical note

Publisher Copyright:
© 2019 Park et al.

Keywords

Brain PET
Cognitive training
Mild cognitive impairment

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10.2147/CIA.S200269

Cite this

@article{aff5f71cf28145d898aebcc031045691,

title = "Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment",

abstract = "Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.",

keywords = "Brain PET, Cognitive training, Mild cognitive impairment",

author = "Jinse Park and Kim, \{Si Eun\} and Kim, \{Eun Joo\} and Lee, \{Byung In\} and Jeong, \{Jee Hyang\} and Na, \{Hae Ri\} and Choi, \{Seong Hye\} and Kang, \{Do Young\} and Park, \{Kyung Won\}",

note = "Publisher Copyright: {\textcopyright} 2019 Park et al.",

year = "2019",

doi = "10.2147/CIA.S200269",

language = "English",

volume = "14",

pages = "1167--1175",

journal = "Clinical Interventions in Aging",

issn = "1176-9092",

publisher = "Dove Medical Press Ltd",

}

TY - JOUR

T1 - Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

AU - Park, Jinse

AU - Kim, Si Eun

AU - Kim, Eun Joo

AU - Lee, Byung In

AU - Jeong, Jee Hyang

AU - Na, Hae Ri

AU - Choi, Seong Hye

AU - Kang, Do Young

AU - Park, Kyung Won

PY - 2019

Y1 - 2019

N2 - Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

AB - Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

KW - Brain PET

KW - Cognitive training

KW - Mild cognitive impairment

UR - https://www.scopus.com/pages/publications/85069709290

U2 - 10.2147/CIA.S200269

DO - 10.2147/CIA.S200269

M3 - Article

C2 - 31303750

AN - SCOPUS:85069709290

SN - 1176-9092

VL - 14

SP - 1167

EP - 1175

JO - Clinical Interventions in Aging

JF - Clinical Interventions in Aging

ER -

Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Abstract

Bibliographical note

Keywords

Access to Document

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Cite this