@article{aff5f71cf28145d898aebcc031045691,
title = "Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment",
abstract = "Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.",
keywords = "Brain PET, Cognitive training, Mild cognitive impairment",
author = "Jinse Park and Kim, {Si Eun} and Kim, {Eun Joo} and Lee, {Byung In} and Jeong, {Jee Hyang} and Na, {Hae Ri} and Choi, {Seong Hye} and Kang, {Do Young} and Park, {Kyung Won}",
note = "Funding Information: This study was supported by a grant from the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) [2014M3C7A1064752] and Eisai Korea Inc. The abstract of this paper was presented at the Alzheimer{\textquoteright}s Association International Conference (AAIC) in Chicago (July 22–26, 2018) as a poster presentation with interim findings. The poster{\textquoteright}s abstract was published in “Poster Abstracts” in Alzheimer{\textquoteright}s & Dementia. Publisher Copyright: {\textcopyright} 2019 Park et al.",
year = "2019",
doi = "10.2147/CIA.S200269",
language = "English",
volume = "14",
pages = "1167--1175",
journal = "Clinical Interventions in Aging",
issn = "1176-9092",
publisher = "Dove Medical Press Ltd.",
}