Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Jinse Park, Si Eun Kim, Eun Joo Kim, Byung In Lee, Jee Hyang Jeong, Hae Ri Na, Seong Hye Choi, Do Young Kang, Kyung Won Park

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

Original languageEnglish
Pages (from-to)1167-1175
Number of pages9
JournalClinical Interventions in Aging
Volume14
DOIs
StatePublished - 2019

Bibliographical note

Publisher Copyright:
© 2019 Park et al.

Keywords

  • Brain PET
  • Cognitive training
  • Mild cognitive impairment

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