Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia

Chun Shu Piao; Young Mi Yu; Pyung Lim Han; Ja Kyeong Lee

doi:10.1016/S0006-8993(03)02579-4

Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia

Chun Shu Piao, Young Mi Yu, Pyung Lim Han, Ja Kyeong Lee

Divison of Brain & Cognitive Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Here we report the dynamically regulated expression of p38β MAPK isoform in specific subsets of cells in postischemic brain. The activity of p38β MAPK in the postischemic brain revealed biphasic induction at 30 min and 4 days after 1 h MCAO. During the early surge period, p38β MAPK was preferentially localized in the nucleus and dendrites of neurons in the future infarction area, while during the delayed surge p38β MAPK was heavily induced in reactive astrocytes in penumbra. The temporally and spatially regulated pattern of p38β MAPK expression in the postischemic brain suggests distinct roles of p38β MAPK in neuronal death and in the astrocyte activation.

Original language	English
Pages (from-to)	120-124
Number of pages	5
Journal	Brain Research
Volume	976
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(03)02579-4
State	Published - 20 Jun 2003

Bibliographical note

Funding Information:
This work was supported by a grant from the 21C Frontier Program from KMOST (FG01-0400-010-1-0-0) for J-K Lee.

Keywords

Astrocyte
Delayed neuronal death
Focal ischemia
p38β MAPK

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10.1016/S0006-8993(03)02579-4

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title = "Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia",

abstract = "Here we report the dynamically regulated expression of p38β MAPK isoform in specific subsets of cells in postischemic brain. The activity of p38β MAPK in the postischemic brain revealed biphasic induction at 30 min and 4 days after 1 h MCAO. During the early surge period, p38β MAPK was preferentially localized in the nucleus and dendrites of neurons in the future infarction area, while during the delayed surge p38β MAPK was heavily induced in reactive astrocytes in penumbra. The temporally and spatially regulated pattern of p38β MAPK expression in the postischemic brain suggests distinct roles of p38β MAPK in neuronal death and in the astrocyte activation.",

keywords = "Astrocyte, Delayed neuronal death, Focal ischemia, p38β MAPK",

author = "Piao, {Chun Shu} and Yu, {Young Mi} and Han, {Pyung Lim} and Lee, {Ja Kyeong}",

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AU - Piao, Chun Shu

AU - Yu, Young Mi

AU - Han, Pyung Lim

AU - Lee, Ja Kyeong

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N2 - Here we report the dynamically regulated expression of p38β MAPK isoform in specific subsets of cells in postischemic brain. The activity of p38β MAPK in the postischemic brain revealed biphasic induction at 30 min and 4 days after 1 h MCAO. During the early surge period, p38β MAPK was preferentially localized in the nucleus and dendrites of neurons in the future infarction area, while during the delayed surge p38β MAPK was heavily induced in reactive astrocytes in penumbra. The temporally and spatially regulated pattern of p38β MAPK expression in the postischemic brain suggests distinct roles of p38β MAPK in neuronal death and in the astrocyte activation.

AB - Here we report the dynamically regulated expression of p38β MAPK isoform in specific subsets of cells in postischemic brain. The activity of p38β MAPK in the postischemic brain revealed biphasic induction at 30 min and 4 days after 1 h MCAO. During the early surge period, p38β MAPK was preferentially localized in the nucleus and dendrites of neurons in the future infarction area, while during the delayed surge p38β MAPK was heavily induced in reactive astrocytes in penumbra. The temporally and spatially regulated pattern of p38β MAPK expression in the postischemic brain suggests distinct roles of p38β MAPK in neuronal death and in the astrocyte activation.

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Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia

Abstract

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Keywords

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