Dumulmycin, an antitubercular bicyclic macrolide from a riverine sediment-derived streptomyces sp.

Joon Soo An, Bora Shin, Tae Ho Kim, Sunghoon Hwang, Yern Hyerk Shin, Jinsheng Cui, Young Eun Du, Jungwoo Yi, Sang Jip Nam, Suckchang Hong, Jongheon Shin, Jichan Jang, Yeo Joon Yoon, Dong Chan Oh

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 μM).

Original languageEnglish
Pages (from-to)3359-3363
Number of pages5
JournalOrganic Letters
Volume23
Issue number9
DOIs
StatePublished - 7 May 2021

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