Dual-phase 18F-florbetaben PET provides cerebral perfusion proxy along with beta-amyloid burden in Alzheimer's disease

Hai Jeon Yoon, Bom Sahn Kim, Jee Hyang Jeong, Geon Ha Kim, Hee Kyung Park, Min Young Chun, Seunggyun Ha

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: This study investigated changes in brain perfusion and Aβ burden according to the progression of Alzheimer's disease (AD) by using a dual-phase 18F-florbetaben (FBB) PET protocol. Methods: Sixty subjects, including 12 with Aβ-negative normal cognition (AβNC), 32 with Aβ-positive mild cognitive impairment (Aβ+MCI), and 16 with Aβ-positive AD (Aβ+AD), were enrolled. A dynamic PET scan was obtained in the early phase (0–10 min, eFBB) and delayed phase (90–110 min, dFBB), which were then averaged into a single frame, respectively. In addition to the averaged eFBB, an R1 parametric map was calculated from the eFBB scan based on a simplified reference tissue model (SRTM). Between-group regional and voxel-wise analyses of the images were performed. The associations between cognitive profiles and PET-derived parameters were investigated. Results: Both the R1 and eFBB perfusion reductions in the cortical regions were not significantly different between the AβNC and Aβ+MCI groups, while they were significantly reduced from the Aβ+MCI to Aβ+AD groups in regional and voxel-wise analyses. However, cortical Aβ depositions on dFBB were not significantly different between the Aβ+MCI and Aβ+AD groups. There were strong positive correlations between the R1 and eFBB images in regional and voxel-wise analyses. Both perfusion components showed significant correlations with general and specific cognitive profiles. Conclusion: The results of this study demonstrated the feasibility of dual-phase 18F-FBB PET to evaluate different trajectories of dual biomarkers for neurodegeneration and Aβ burden over the course of AD. In addition, both eFBB and SRTM-based R1 can provide robust indices of brain perfusion.

Original languageEnglish
Article number102773
JournalNeuroImage: Clinical
Volume31
DOIs
StatePublished - Jan 2021

Keywords

  • Alzheimer's disease
  • Dual-phase
  • F-florbetaben
  • Positron emission tomography
  • R1

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