Dual oxidase in mucosal immunity and host-microbe homeostasis

Yun Soo Bae, Myoung Kwon Choi, Won Jae Lee

Research output: Contribution to journalReview articlepeer-review

151 Scopus citations

Abstract

Mucosal epithelia are in direct contact with microbes, which range from beneficial symbionts to pathogens. Accordingly, hosts must have a conflicting strategy to combat pathogens efficiently while tolerating symbionts. Recent progress has revealed that dual oxidase (DUOX) plays a key role in mucosal immunity in organisms that range from flies to humans. Information from the genetic model of Drosophila has advanced our understanding of the regulatory mechanism of DUOX and its role in mucosal immunity. Further investigations of DUOX regulation in response to symbiotic or non-symbiotic bacteria and the in vivo consequences in host physiology will give a novel insight into the microbe-controlling system of the mucosa.

Original languageEnglish
Pages (from-to)278-287
Number of pages10
JournalTrends in Immunology
Volume31
Issue number7
DOIs
StatePublished - Jul 2010

Fingerprint

Dive into the research topics of 'Dual oxidase in mucosal immunity and host-microbe homeostasis'. Together they form a unique fingerprint.

Cite this