Dual functions of nanoplasmonic optical antennas: Nanoplasmonic gene switches and biosensors

Somin Eunice Lee; Younggeun Park; Taewook Kang; Luke P. Lee

doi:10.1007/978-1-4614-3933-2_4

Dual functions of nanoplasmonic optical antennas: Nanoplasmonic gene switches and biosensors

Somin Eunice Lee, Younggeun Park, Taewook Kang, Luke P. Lee

Department of Chemistry & Nanoscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Within a living cell, the intracellular distribution is spatially nonuniform and dynamically changing over time in response to environmental cues. By focusing on electromagnetic fields down to dimensions smaller than the diffraction limit, nanoplasmonic optical antennas, functioning as nanoplasmonic gene switches, enable on- demand and spatially precise regulation of genetic activity to give rise to location-specific function. In addition to on-demand gene regulation, nanoplasmonic optical antennas also function as label-free biosensors that significantly enhance spectral information for plasmon resonance energy transfer, surface-enhanced Raman spectroscopy, and nanoplasmonic molecular rulers. "Spectral snapshots" (i.e., spectroscopic imaging) of the dynamically changing intracellular biochemical distribution can be obtained over time.

Original language	English
Title of host publication	Nanoplasmonic Sensors
Publisher	Springer New York
Pages	83-104
Number of pages	22
ISBN (Electronic)	9781461439332
ISBN (Print)	9781461439325
DOIs	https://doi.org/10.1007/978-1-4614-3933-2_4
State	Published - 1 Jan 2012

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© Springer Science+Business Media New York 2012. All rights are reserved.

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Dual functions of nanoplasmonic optical antennas: Nanoplasmonic gene switches and biosensors

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