TY - JOUR
T1 - Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers
AU - Jeong, Byeongmoon
AU - Bae, You Han
AU - Kim, Sung Wan
N1 - Funding Information:
This work was supported by the University of Utah Research Foundation.
PY - 2000/1/3
Y1 - 2000/1/3
N2 - An aqueous solution of newly developed low-molecular-weight PEG-PLGA-PEG triblock copolymers with a specific composition is a free flowing sol at room temperature but becomes a gel at body temperature. Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37°C aqueous environment. Ketoprofen (a model hydrophilic drug) was released over 2 weeks with a first-order release profile, while spironolactone (a model hydrophobic drug) was released over 2 months with an S-shaped release profile. The release profiles were simulated by models considering degradation and diffusion, and were better described by a model assuming a core-shell structure of the gel.
AB - An aqueous solution of newly developed low-molecular-weight PEG-PLGA-PEG triblock copolymers with a specific composition is a free flowing sol at room temperature but becomes a gel at body temperature. Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37°C aqueous environment. Ketoprofen (a model hydrophilic drug) was released over 2 weeks with a first-order release profile, while spironolactone (a model hydrophobic drug) was released over 2 months with an S-shaped release profile. The release profiles were simulated by models considering degradation and diffusion, and were better described by a model assuming a core-shell structure of the gel.
KW - Biodegradable hydrogel
KW - Drug release model
KW - Injectable formulation
KW - Sol-gel transition, In situ gel
UR - http://www.scopus.com/inward/record.url?scp=0142210489&partnerID=8YFLogxK
U2 - 10.1016/S0168-3659(99)00194-7
DO - 10.1016/S0168-3659(99)00194-7
M3 - Article
C2 - 10640589
AN - SCOPUS:0142210489
VL - 63
SP - 155
EP - 163
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
IS - 1-2
ER -