Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers

Byeongmoon Jeong; You Han Bae; Sung Wan Kim

doi:10.1016/S0168-3659(99)00194-7

Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers

Byeongmoon Jeong, You Han Bae, Sung Wan Kim

Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

584 Scopus citations

Abstract

An aqueous solution of newly developed low-molecular-weight PEG-PLGA-PEG triblock copolymers with a specific composition is a free flowing sol at room temperature but becomes a gel at body temperature. Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37°C aqueous environment. Ketoprofen (a model hydrophilic drug) was released over 2 weeks with a first-order release profile, while spironolactone (a model hydrophobic drug) was released over 2 months with an S-shaped release profile. The release profiles were simulated by models considering degradation and diffusion, and were better described by a model assuming a core-shell structure of the gel.

Original language	English
Pages (from-to)	155-163
Number of pages	9
Journal	Journal of Controlled Release
Volume	63
Issue number	1-2
DOIs	https://doi.org/10.1016/S0168-3659(99)00194-7
State	Published - 3 Jan 2000

Bibliographical note

Funding Information:
This work was supported by the University of Utah Research Foundation.

Keywords

Biodegradable hydrogel
Drug release model
Injectable formulation
Sol-gel transition, In situ gel

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10.1016/S0168-3659(99)00194-7

Cite this

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title = "Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers",

abstract = "An aqueous solution of newly developed low-molecular-weight PEG-PLGA-PEG triblock copolymers with a specific composition is a free flowing sol at room temperature but becomes a gel at body temperature. Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37°C aqueous environment. Ketoprofen (a model hydrophilic drug) was released over 2 weeks with a first-order release profile, while spironolactone (a model hydrophobic drug) was released over 2 months with an S-shaped release profile. The release profiles were simulated by models considering degradation and diffusion, and were better described by a model assuming a core-shell structure of the gel.",

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KW - Drug release model

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Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers

Abstract

Bibliographical note

Keywords

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