Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers

Byeongmoon Jeong, You Han Bae, Sung Wan Kim

Research output: Contribution to journalArticlepeer-review

549 Scopus citations

Abstract

An aqueous solution of newly developed low-molecular-weight PEG-PLGA-PEG triblock copolymers with a specific composition is a free flowing sol at room temperature but becomes a gel at body temperature. Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37°C aqueous environment. Ketoprofen (a model hydrophilic drug) was released over 2 weeks with a first-order release profile, while spironolactone (a model hydrophobic drug) was released over 2 months with an S-shaped release profile. The release profiles were simulated by models considering degradation and diffusion, and were better described by a model assuming a core-shell structure of the gel.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalJournal of Controlled Release
Volume63
Issue number1-2
DOIs
StatePublished - 3 Jan 2000

Keywords

  • Biodegradable hydrogel
  • Drug release model
  • Injectable formulation
  • Sol-gel transition, In situ gel

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