Drug persistency of cholinesterase inhibitors for patients with dementia of Alzheimer type in Korea

So Hyeon Ahn, Nam Kyong Choi, Ye Jee Kim, Jong Mi Seong, Ju Young Shin, Sun Young Jung, Byung Joo Park

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


This study examined 1-year persistency with cholinesterase inhibitors (ChEIs) for the treatment of elderly Alzheimer's dementia (AD) patients in Korea. Korean Health Insurance Review & Assessment Service database from January 2005 to June 2006 was used. Patients aged 65 or older with AD diagnosis who were first prescribed a ChEI were included. The 1-year persistence, persistency rate, and switching patterns during the follow-up period were identified. Mean time to drug discontinuation was analyzed, and persistency rates between different patient factors were compared. The 1-year persistency rate of newly treated 6,461 AD patients was 24.0 %, while 50 % of study patients discontinued treatment by 91 days from initiation. Persistency rates of female patients (22.8 %), patients in rural areas (12.7 %), and primary care (10.2 %) were relatively low (p < 0.001). Persistency rate differed between age groups (p < 0.001). Overall proportion of switching was 6.6 %. The 1-year persistency rate of ChEIs for AD patients in Korea did not reach those of previous researches in other countries. Patients less likely to remain on therapy should be especially monitored to optimize treatment persistence.

Original languageEnglish
Pages (from-to)1255-1262
Number of pages8
JournalArchives of Pharmacal Research
Issue number6
StatePublished - 22 Oct 2015

Bibliographical note

Publisher Copyright:
© 2014 The Pharmaceutical Society of Korea.


  • Cholinesterase inhibitors
  • Dementia, Alzheimer type
  • Elderly
  • Medication persistence
  • Pharmacoepidemiology


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