Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting

Kyungim Kim; Keun Sang Oh; Dal Yong Park; Jae Young Lee; Beom Suk Lee; In San Kim; Kwangmeyung Kim; Ick Chan Kwon; Yoon Kim Sang; Soon Hong Yuk

doi:10.1016/j.jconrel.2016.03.009

Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting

Kyungim Kim
, Keun Sang Oh
, Dal Yong Park
, Jae Young Lee
, Beom Suk Lee
, In San Kim
, Kwangmeyung Kim
, Ick Chan Kwon
, Yoon Kim Sang
, Soon Hong Yuk

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.

Original language	English
Pages (from-to)	141-149
Number of pages	9
Journal	Journal of Controlled Release
Volume	228
DOIs	https://doi.org/10.1016/j.jconrel.2016.03.009
State	Published - 28 Apr 2016

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ) and National R&D Program for Cancer Control, Ministry of Health and Welfare , Republic of Korea ( 1420390 ).

Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.

Keywords

Combination therapy
Core/shell nanoparticles
Doxorubicin
Gold nanoparticles
Radiotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jconrel.2016.03.009

Cite this

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title = "Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting",

abstract = "A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.",

keywords = "Combination therapy, Core/shell nanoparticles, Doxorubicin, Gold nanoparticles, Radiotherapy",

author = "Kyungim Kim and Oh, \{Keun Sang\} and Park, \{Dal Yong\} and Lee, \{Jae Young\} and Lee, \{Beom Suk\} and Kim, \{In San\} and Kwangmeyung Kim and Kwon, \{Ick Chan\} and Sang, \{Yoon Kim\} and Yuk, \{Soon Hong\}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ) and National R\&D Program for Cancer Control, Ministry of Health and Welfare , Republic of Korea ( 1420390 ). Publisher Copyright: {\textcopyright} 2016 Elsevier B.V. All rights reserved.",

year = "2016",

month = apr,

day = "28",

doi = "10.1016/j.jconrel.2016.03.009",

language = "English",

volume = "228",

pages = "141--149",

journal = "Journal of Controlled Release",

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T1 - Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting

AU - Kim, Kyungim

AU - Oh, Keun Sang

AU - Park, Dal Yong

AU - Lee, Jae Young

AU - Lee, Beom Suk

AU - Kim, In San

AU - Kim, Kwangmeyung

AU - Kwon, Ick Chan

AU - Sang, Yoon Kim

AU - Yuk, Soon Hong

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ) and National R&D Program for Cancer Control, Ministry of Health and Welfare , Republic of Korea ( 1420390 ). Publisher Copyright: © 2016 Elsevier B.V. All rights reserved.

PY - 2016/4/28

Y1 - 2016/4/28

N2 - A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.

AB - A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.

KW - Combination therapy

KW - Core/shell nanoparticles

KW - Doxorubicin

KW - Gold nanoparticles

KW - Radiotherapy

UR - https://www.scopus.com/pages/publications/84960931563

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DO - 10.1016/j.jconrel.2016.03.009

M3 - Article

C2 - 26970205

AN - SCOPUS:84960931563

SN - 0168-3659

VL - 228

SP - 141

EP - 149

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting

Abstract

Bibliographical note

Keywords

UN SDGs

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