Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting

Kyungim Kim, Keun Sang Oh, Dal Yong Park, Jae Young Lee, Beom Suk Lee, In San Kim, Kwangmeyung Kim, Ick Chan Kwon, Yoon Kim Sang, Soon Hong Yuk

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalJournal of Controlled Release
Volume228
DOIs
StatePublished - 28 Apr 2016

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ) and National R&D Program for Cancer Control, Ministry of Health and Welfare , Republic of Korea ( 1420390 ).

Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.

Keywords

  • Combination therapy
  • Core/shell nanoparticles
  • Doxorubicin
  • Gold nanoparticles
  • Radiotherapy

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