Abstract
A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.
Original language | English |
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Pages (from-to) | 141-149 |
Number of pages | 9 |
Journal | Journal of Controlled Release |
Volume | 228 |
DOIs | |
State | Published - 28 Apr 2016 |
Bibliographical note
Funding Information:This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ) and National R&D Program for Cancer Control, Ministry of Health and Welfare , Republic of Korea ( 1420390 ).
Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.
Keywords
- Combination therapy
- Core/shell nanoparticles
- Doxorubicin
- Gold nanoparticles
- Radiotherapy