Down-regulation of transglutaminase II leads to impaired motility of cancer cells by inactivation of the protein kinase, Akt, and decrease of reactive oxygen species

Jinhee Bae; Yun Sil Lee; Dooil Jeoung

doi:10.1007/s10529-006-9079-6

Down-regulation of transglutaminase II leads to impaired motility of cancer cells by inactivation of the protein kinase, Akt, and decrease of reactive oxygen species

Jinhee Bae, Yun Sil Lee, Dooil Jeoung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We employed RNA interference to determine the role of tissue transglutaminase II (TGase II) in motility of cancer cells. Down-regulation of TGase II by small interfering RNA against TGase II impaired adhesion and motility of HeLa cells by decreasing phosphorylation of the protein kinase, Akt, and reactive oxygen species (ROS). Over-expression of TGase II showed opposite effects. These results suggest potential utility of TGase II for development of therapeutic anti cancer vaccine.

Original language	English
Pages (from-to)	1151-1158
Number of pages	8
Journal	Biotechnology Letters
Volume	28
Issue number	15
DOIs	https://doi.org/10.1007/s10529-006-9079-6
State	Published - Aug 2006

Bibliographical note

Funding Information:
Acknowledgments This work was supported by a grant from (0103026-1-2) from the Basic Research Program of the Korea Science & Engineering Foundation, a grant from Korea Research Foundation and Vascular System Research Center, a grant from Korea Research Foundation (0805011-1-1), and a grant (A050260) from the Ministry of Health and Welfare of Korea.

Keywords

Akt
Motility
Reactive oxygen species
Small interfering RNA
Transglutaminase II

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10529-006-9079-6

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title = "Down-regulation of transglutaminase II leads to impaired motility of cancer cells by inactivation of the protein kinase, Akt, and decrease of reactive oxygen species",

abstract = "We employed RNA interference to determine the role of tissue transglutaminase II (TGase II) in motility of cancer cells. Down-regulation of TGase II by small interfering RNA against TGase II impaired adhesion and motility of HeLa cells by decreasing phosphorylation of the protein kinase, Akt, and reactive oxygen species (ROS). Over-expression of TGase II showed opposite effects. These results suggest potential utility of TGase II for development of therapeutic anti cancer vaccine.",

keywords = "Akt, Motility, Reactive oxygen species, Small interfering RNA, Transglutaminase II",

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doi = "10.1007/s10529-006-9079-6",

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AU - Lee, Yun Sil

AU - Jeoung, Dooil

N1 - Funding Information: Acknowledgments This work was supported by a grant from (0103026-1-2) from the Basic Research Program of the Korea Science & Engineering Foundation, a grant from Korea Research Foundation and Vascular System Research Center, a grant from Korea Research Foundation (0805011-1-1), and a grant (A050260) from the Ministry of Health and Welfare of Korea.

PY - 2006/8

Y1 - 2006/8

N2 - We employed RNA interference to determine the role of tissue transglutaminase II (TGase II) in motility of cancer cells. Down-regulation of TGase II by small interfering RNA against TGase II impaired adhesion and motility of HeLa cells by decreasing phosphorylation of the protein kinase, Akt, and reactive oxygen species (ROS). Over-expression of TGase II showed opposite effects. These results suggest potential utility of TGase II for development of therapeutic anti cancer vaccine.

AB - We employed RNA interference to determine the role of tissue transglutaminase II (TGase II) in motility of cancer cells. Down-regulation of TGase II by small interfering RNA against TGase II impaired adhesion and motility of HeLa cells by decreasing phosphorylation of the protein kinase, Akt, and reactive oxygen species (ROS). Over-expression of TGase II showed opposite effects. These results suggest potential utility of TGase II for development of therapeutic anti cancer vaccine.

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KW - Motility

KW - Reactive oxygen species

KW - Small interfering RNA

KW - Transglutaminase II

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Down-regulation of transglutaminase II leads to impaired motility of cancer cells by inactivation of the protein kinase, Akt, and decrease of reactive oxygen species

Abstract

Bibliographical note

Keywords

UN SDGs

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