Down-regulation of transglutaminase II leads to impaired motility of cancer cells by inactivation of the protein kinase, Akt, and decrease of reactive oxygen species

Jinhee Bae, Yun Sil Lee, Dooil Jeoung

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We employed RNA interference to determine the role of tissue transglutaminase II (TGase II) in motility of cancer cells. Down-regulation of TGase II by small interfering RNA against TGase II impaired adhesion and motility of HeLa cells by decreasing phosphorylation of the protein kinase, Akt, and reactive oxygen species (ROS). Over-expression of TGase II showed opposite effects. These results suggest potential utility of TGase II for development of therapeutic anti cancer vaccine.

Original languageEnglish
Pages (from-to)1151-1158
Number of pages8
JournalBiotechnology Letters
Volume28
Issue number15
DOIs
StatePublished - Aug 2006

Keywords

  • Akt
  • Motility
  • Reactive oxygen species
  • Small interfering RNA
  • Transglutaminase II

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