Abstract
Adipose-derived stem cells represent a type of mesenchymal stem cells with the attendant capacity to self-renew and differentiate into multiple cell lineages. We have performed a microarray-based gene expression profiling of osteogenic differentiation and found that the transcription factor Sox11 is down-regulated during the process. Functional assays demonstrate that down-regulation of Sox11 is required for an efficient differentiation. Furthermore, results from forced expression of constitutively-active and dominant-negative derivatives of Sox11 indicate that Sox11 functions as a transcriptional activator in inhibiting osteogenesis. Sox11 thus represents a novel regulator of osteogenesis whose expression and activity can be potentially manipulated for controlled differentiation.
Original language | English |
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Pages (from-to) | 337-344 |
Number of pages | 8 |
Journal | Molecules and Cells |
Volume | 37 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2014 |
Keywords
- Adipose-derived stem cell
- Differentiation
- Mesenchymal stem cell
- Osteogenesis
- Sox11