Down-regulation of Sox11 is required for efficient osteogenic differentiation of adipose-derived stem cells

Mi Kyung Choi, Ikjoo Seong, Seon Ah Kang, Jaesang Kim

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Adipose-derived stem cells represent a type of mesenchymal stem cells with the attendant capacity to self-renew and differentiate into multiple cell lineages. We have performed a microarray-based gene expression profiling of osteogenic differentiation and found that the transcription factor Sox11 is down-regulated during the process. Functional assays demonstrate that down-regulation of Sox11 is required for an efficient differentiation. Furthermore, results from forced expression of constitutively-active and dominant-negative derivatives of Sox11 indicate that Sox11 functions as a transcriptional activator in inhibiting osteogenesis. Sox11 thus represents a novel regulator of osteogenesis whose expression and activity can be potentially manipulated for controlled differentiation.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalMolecules and Cells
Volume37
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Adipose-derived stem cell
  • Differentiation
  • Mesenchymal stem cell
  • Osteogenesis
  • Sox11

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