@article{625ba55b69da4b43bd2771c241ee607a,
title = "Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells",
abstract = "The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.",
keywords = "C-FLIP, Motility, Reactive oxygen species, Serine/threonine kinase Akt",
author = "Eunsook Shim and Lee, {Yun Sil} and Kim, {Hae Yeong} and Dooil Jeoung",
note = "Funding Information: Acknowledgements This work was supported by grants from the Basic Research Program of the Korea Science & Engineering Foundation (0103026-1-2), Korea Research Foundation and Vascular System Research Center, Korea Research Foundation Grant (C00249) funded by the Korean Government (MOEHRD), and a grant from the Ministry of Health and Welfare of Korea (A050260).",
year = "2007",
month = jan,
doi = "10.1007/s10529-006-9213-5",
language = "English",
volume = "29",
pages = "141--147",
journal = "Biotechnology Letters",
issn = "0141-5492",
publisher = "Springer Netherlands",
number = "1",
}
