Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells

Eunsook Shim; Yun Sil Lee; Hae Yeong Kim; Dooil Jeoung

doi:10.1007/s10529-006-9213-5

Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells

Eunsook Shim, Yun Sil Lee, Hae Yeong Kim, Dooil Jeoung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.

Original language	English
Pages (from-to)	141-147
Number of pages	7
Journal	Biotechnology Letters
Volume	29
Issue number	1
DOIs	https://doi.org/10.1007/s10529-006-9213-5
State	Published - Jan 2007

Bibliographical note

Funding Information:
Acknowledgements This work was supported by grants from the Basic Research Program of the Korea Science & Engineering Foundation (0103026-1-2), Korea Research Foundation and Vascular System Research Center, Korea Research Foundation Grant (C00249) funded by the Korean Government (MOEHRD), and a grant from the Ministry of Health and Welfare of Korea (A050260).

Keywords

C-FLIP
Motility
Reactive oxygen species
Serine/threonine kinase Akt

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10529-006-9213-5

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title = "Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells",

abstract = "The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.",

keywords = "C-FLIP, Motility, Reactive oxygen species, Serine/threonine kinase Akt",

author = "Eunsook Shim and Lee, {Yun Sil} and Kim, {Hae Yeong} and Dooil Jeoung",

note = "Funding Information: Acknowledgements This work was supported by grants from the Basic Research Program of the Korea Science & Engineering Foundation (0103026-1-2), Korea Research Foundation and Vascular System Research Center, Korea Research Foundation Grant (C00249) funded by the Korean Government (MOEHRD), and a grant from the Ministry of Health and Welfare of Korea (A050260).",

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AU - Shim, Eunsook

AU - Lee, Yun Sil

AU - Kim, Hae Yeong

AU - Jeoung, Dooil

N1 - Funding Information: Acknowledgements This work was supported by grants from the Basic Research Program of the Korea Science & Engineering Foundation (0103026-1-2), Korea Research Foundation and Vascular System Research Center, Korea Research Foundation Grant (C00249) funded by the Korean Government (MOEHRD), and a grant from the Ministry of Health and Welfare of Korea (A050260).

PY - 2007/1

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AB - The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.

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KW - Motility

KW - Reactive oxygen species

KW - Serine/threonine kinase Akt

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ER -

Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells

Abstract

Bibliographical note

Keywords

UN SDGs

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