The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.
Bibliographical noteFunding Information:
Acknowledgements This work was supported by grants from the Basic Research Program of the Korea Science & Engineering Foundation (0103026-1-2), Korea Research Foundation and Vascular System Research Center, Korea Research Foundation Grant (C00249) funded by the Korean Government (MOEHRD), and a grant from the Ministry of Health and Welfare of Korea (A050260).
- Reactive oxygen species
- Serine/threonine kinase Akt