Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells

Eunsook Shim, Yun Sil Lee, Hae Yeong Kim, Dooil Jeoung

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalBiotechnology Letters
Volume29
Issue number1
DOIs
StatePublished - Jan 2007

Bibliographical note

Funding Information:
Acknowledgements This work was supported by grants from the Basic Research Program of the Korea Science & Engineering Foundation (0103026-1-2), Korea Research Foundation and Vascular System Research Center, Korea Research Foundation Grant (C00249) funded by the Korean Government (MOEHRD), and a grant from the Ministry of Health and Welfare of Korea (A050260).

Keywords

  • C-FLIP
  • Motility
  • Reactive oxygen species
  • Serine/threonine kinase Akt

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