TY - JOUR
T1 - Dose-incidence relationships on the prenatal effects of gamma-radiation in mice.
AU - Bang, Dae won
AU - Lee, Jong hwan
AU - Oh, Heon
AU - Kim, Se ra
AU - Kim, Tae hwan
AU - Lee, Yun sil
AU - Lee, Cha soo
AU - Kim, Sung ho
PY - 2002/3
Y1 - 2002/3
N2 - The objective of this investigation was to evaluate dose-incidence relationships on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed on day 11.5 after conception, coincident with the most sensitive stage for the induction of major congenital malformations, with 0.5-4.0 Gy of gamma-radiations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. With increasing radiation dose, incidence of small head, growth retarded fetuses, cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose. The threshold doses of radiation that induced cleft palate and dilatation of cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively.
AB - The objective of this investigation was to evaluate dose-incidence relationships on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed on day 11.5 after conception, coincident with the most sensitive stage for the induction of major congenital malformations, with 0.5-4.0 Gy of gamma-radiations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. With increasing radiation dose, incidence of small head, growth retarded fetuses, cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose. The threshold doses of radiation that induced cleft palate and dilatation of cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0642277989&partnerID=8YFLogxK
U2 - 10.4142/jvs.2002.3.1.7
DO - 10.4142/jvs.2002.3.1.7
M3 - Article
C2 - 14614266
AN - SCOPUS:0642277989
SN - 1229-845X
VL - 3
SP - 7
EP - 11
JO - Journal of Veterinary Science
JF - Journal of Veterinary Science
IS - 1
ER -