@article{c084eaac48f14651b8b4539f1b06b5c0,
title = "Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY)",
abstract = "Data for Asian kidney transplants are very limited. We investigated the relative importance of prognostic markers in Asian kidney transplants by using Korean Organ Transplantation Registry (KOTRY) cohort. Prediction models were developed by data-driven variable selection approach. The relative importance of the selected predictors was measured by dominance analysis. A total of 4854 kidney transplant donor-recipient pairs were analyzed. Overall patient survival rates were 99.8%, 98.8%, and 91.8% at 1, 3, and 5 years, respectively. Death-censored graft survival rates were 98.4%, 97.0%, and 95.8% at 1, 3, and 5 years. Biopsy-proven acute rejection free survival rates were 90.1%, 87.4%, and 87.03% at 1, 3, and 5 years. The top 3 dominant predictors for recipient mortality within 1 year were recipient cardiovascular disease history, deceased donor, and recipient age. The dominant predictors for death-censored graft loss within 1 year were acute rejection, deceased donor, and desensitization. The dominant predictors to acute rejection within 1 year were donor age, HLA mismatched numbers, and desensitization. We presented clinical characteristics of patients enrolled in KOTRY during the last 5 years and investigated dominant predictors for early post-transplant outcomes, which would be useful for clinical decision-making based on quantitative measures.",
author = "{The KOTRY Study Group} and Jeong, {Jong Cheol} and Koo, {Tai Yeon} and Han Ro and Lee, {Dong Ryeol} and Lee, {Dong Won} and Jayoun Kim and Chae, {Dong Wan} and Kim, {Young Hoon} and Huh, {Kyu Ha} and Park, {Jae Berm} and Kim, {Yeong Hoon} and Seungyeup Han and Choi, {Soo Jin Na} and Sik Lee and Min, {Sang Il} and Jongwon Ha and Kim, {Myoung Soo} and Curie Ahn and Jaeseok Yang and Curie Ahn and Kim, {Myoung Soo} and Kong, {Jin Min} and Kwon, {Oh Jung} and Kim, {Deok Gie} and Jung, {Cheol Woong} and Kim, {Yeong Hoon} and Kim, {Joong Kyung} and Kim, {Chan Duck} and Min, {Ji Won} and Park, {Sung Kwang} and Park, {Yeon Ho} and Park, {Jae Berm} and Park, {Jung Hwan} and Song, {Sang Heon} and Ban, {Tae Hyun} and Song, {Seung Hwan} and Shin, {Ho Sik} and Yang, {Chul Woo} and Lee, {Dong Ryeol} and Lee, {Dong Won} and Lee, {Sam Yeol} and Lee, {Sang Ho} and Lee, {Su Hyung} and Lee, {Yu Ho} and Lee, {Jung Pyo} and Lee, {Jeong Hoon} and Jeon, {Jin Seok} and Heungman Jun and Kyunghwan Jeong and Chung, {Ku Yong}",
note = "Funding Information: This research was supported by a fund (2014-ER6301-00, 2014-ER6301-01, 2014-ER6301-02, 2017-ER6301-00, and 2017-ER6301-01) by Research of Korea Centers for Disease Control and Prevention and by a fund of Norvatis. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
day = "1",
doi = "10.1038/s41598-022-12302-5",
language = "English",
volume = "12",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}