Does Teriparatide Improve Fracture Union? A Systematic Review

Byung Ho Yoon, Ki Choul Kim

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

We conducted an updated review of the evidence of teriparatide (TPTD) for fracture healing for the following questions. (1) Does it decrease fracture healing time?; (2) Can it be an alternative treatment for nonunion?; (3) Does it aid the union of atypical femoral fracture (AFF)? We searched PubMed, EMBASE, and Cochrane Library including “Fracture” AND “nonunion” AND “Teriparatide”. In total, 57 publications met our inclusion criteria were summarized. This systemic review of the available literature revealed that TPTD works positively with regard to enhancing fracture healing time and union of AFF. There are also many case studies on the use of TPTD could be a potential new safe treatment for nonunion with no side effects. However, level 1 studies on the evidence of TPTD are still lacking so far. Over the last decade, a growing body of evidence has accumulated suggesting that TPTD can be an adjunct to enhance fracture healing or a therapeutic option to treat nonunion, but greater evidences from large volume prospective trials are needed.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalJournal of Bone Metabolism
Volume27
Issue number3
DOIs
StatePublished - 2020

Keywords

  • Fractures, Bone
  • Parathyroid hormone
  • Teriparatide

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