Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?

Yuri Cho, Dong Hyeon Lee, Yun Bin Lee, Minjong Lee, Jeong Ju Yoo, Won Mook Choi, Young Youn Cho, Jin Chul Paeng, Keon Wook Kang, June Key Chung, Su Jong Yu, Jeong Hoon Lee, Jung Hwan Yoon, Hyo Suk Lee, Yoon Jun Kim

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41 Scopus citations

Abstract

Background and Aim: The utility of fluorine-18 fluorodeoxyglucose ( 18F-FDG) positron emission tomography-computed tomography (PET/CT) in initial staging of hepatocellular carcinoma (HCC) has yet to be fully explored. We assessed the usefulness of 18F-FDG PET/CT in initial staging of HCC. Methods: A total of 457 consecutive patients initially diagnosed with HCC at Seoul National University Hospital between 2006 and 2012 were evaluated retrospectively to assess the impact of 18F-FDG PET/CT on staging and compliancy with Milan criteria, relative to dynamic CT of liver and chest x-ray. Results: Seven among the 457 patients studied showed a shift in Barcelona Clinic Liver Cancer [BCLC] stage (A→C: 6 patients; B→C: 1 patient) and 5 patients who had originally met Milan criteria no longer qualified. 18F-FDG PET/CT had value in initial staging of early (stage A) or intermediate (stage B) HCC, as determined by dynamic CT of liver and BCLC or AJCC classifications, whereas BCLC stage 0 and stage C tumors were unchanged (P<0.001). 18F-FDG PET/CT disclosed additional metastases in patients with American Joint Committee on Cancer [AJCC] T2 (2.7%), T3a (5.3%), and T3b (4.8%) classifications. Conclusions: In initial staging of HCC, 18F-FDG PET/CT provided additional information, impacting the patients with BCLC (stages A and B) and AJCC (T2 and T3) classifications. Its use might be thus appropriate for these patient subsets, especially if hepatic resection or liver transplantation is planned.

Original languageEnglish
Article numbere105679
JournalPLoS ONE
Volume9
Issue number8
DOIs
StatePublished - 25 Aug 2014

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