Does bone mineral density differ between fan-beam and pencil-beam? A meta-analysis and systemic review

Byung Ho Yoon, Young-Do Koh, Jun Il Yoo, Sujin Kim, Guen Young Lee, Sung Bin Park, Yong Chan Ha

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Dual energy X-ray absorptiometry (DXA) has evolved from pencil-beam (PB) to narrow fan-beam (FB) densitometers. We performed a meta-analysis of the available observational studies to determine how different modes of DXA affect bone mineral density (BMD) measurements. Methods: A total of 1,233 patients (808 women) from 14 cohort studies were included. We evaluated the differences in BMD according to the DXA mode: PB and FB. Additionally, we evaluated the differences in BMD between the 2 types of FB mode: FB (Prodigy) and the most recent FB (iDXA). Pairwise meta-analysis was performed, and weighted mean differences (WMD) were calculated for (total lumbar, total hip, and total body). Results: No significant difference was observed in total lumbar (pooled WMD, -0.013; P=0.152) and total hip BMD (pooled WMD, -0.01; P=0.889), between PB and FB. However, total body BMD was significantly lower in the PB compared to the FB group (pooled WMD, -0.014; P=0.024). No significant difference was observed in lumbar BMD (pooled WMD, -0.006; P=0.567), total hip (pooled WMD, -0.002; P=0.821), and total body (pooled WMD, 0.015; P=0.109), between Prodigy and iDXA. Conclusions: The results of this study warrant the recommendation that correction equations should not be used when comparing BMD from different modes. Further research is still needed to highlight the ways in which differences between DXA systems can be minimized.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalJournal of Bone Metabolism
Volume28
Issue number1
DOIs
StatePublished - Feb 2021

Keywords

  • Absorptiometry
  • Bone density
  • Densitometry
  • Osteoporosis
  • Photon

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