Abstract
Docetaxel-loaded composite nanoparticles were prepared by temperature-induced phase transition of a mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing docetaxel. Liquid soybean oil/Tween 80 was used as a solubilizer for docetaxel and Pluronic F-68 to stabilize the liquid soybean oil/Tween 80 containing docetaxel. The phase transition was performed at low temperature to avoid degradation. The docetaxel composite nanoparticles were injected into the tail veins of tumor-bearing mice to evaluate the composite delivery system for the release pattern and the tumor growth. The tumor-targeting capability of composite nanoparticles was verified by noninvasive live animal imaging for the time-dependent excretion profile, the in vivo biodistribution, and the circulation time.
| Original language | English |
|---|---|
| Pages (from-to) | 441-452 |
| Number of pages | 12 |
| Journal | Journal of Bioactive and Compatible Polymers |
| Volume | 27 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2012 |
Bibliographical note
Funding Information:This study was financially supported by the Korea Research Foundation (20110027932 and 2011K000965) and a grant from the fundamental R&D program for core technology of materials funded by the Ministry of Knowledge Economy, Republic of Korea.
Keywords
- Composite nanoparticles
- Tween 80/soybean oil
- antitumor efficacy
- cancer therapy
- docetaxel
- in vivo biodistribution
