Docetaxel-loaded composite nanoparticles formed by a temperature-induced phase transition for cancer therapy

Soon H. Yuk, Keun S. Oh, Jinah Park, Eun H. Lee, Kwangmeyung Kim, Ick C. Kwon

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Docetaxel-loaded composite nanoparticles were prepared by temperature-induced phase transition of a mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing docetaxel. Liquid soybean oil/Tween 80 was used as a solubilizer for docetaxel and Pluronic F-68 to stabilize the liquid soybean oil/Tween 80 containing docetaxel. The phase transition was performed at low temperature to avoid degradation. The docetaxel composite nanoparticles were injected into the tail veins of tumor-bearing mice to evaluate the composite delivery system for the release pattern and the tumor growth. The tumor-targeting capability of composite nanoparticles was verified by noninvasive live animal imaging for the time-dependent excretion profile, the in vivo biodistribution, and the circulation time.

Original languageEnglish
Pages (from-to)441-452
Number of pages12
JournalJournal of Bioactive and Compatible Polymers
Volume27
Issue number5
DOIs
StatePublished - Sep 2012

Keywords

  • antitumor efficacy
  • cancer therapy
  • Composite nanoparticles
  • docetaxel
  • in vivo biodistribution
  • Tween 80/soybean oil

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