Abstract
During our research program to find DNA strand-scission agents from higher plants, the MeOH extracts of the stems of Mucuna birdwoodiana Tutcher. (Leguminosae) exhibited the most potent activity with an IC50 value of 4.9 μg/ml. Thus, detailed laboratory investigation was performed, and led to the isolation of known compounds, (±)-catechin (1) and (-)-epicatechin (2) as active principles. Compounds 1 and 2 showed significant activity of DNA strand-scission with IC50 values of 10.8 and 7.5 μg/ml, respectively (positive control, bleomycin: IC50 3.3 μg/ml).
Original language | English |
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Pages (from-to) | 105-108 |
Number of pages | 4 |
Journal | Natural Product Sciences |
Volume | 9 |
Issue number | 2 |
State | Published - Jun 2003 |
Keywords
- (±)-catechin
- (-)-epicatechin
- DNA strand-scission
- Leguminosae
- Mucuna birdwoodiana