DNA strand-nicking principles of Mucuna birdwoodiana

Ah Reum Han, Woongchon Mar, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


During our research program to find DNA strand-scission agents from higher plants, the MeOH extracts of the stems of Mucuna birdwoodiana Tutcher. (Leguminosae) exhibited the most potent activity with an IC50 value of 4.9 μg/ml. Thus, detailed laboratory investigation was performed, and led to the isolation of known compounds, (±)-catechin (1) and (-)-epicatechin (2) as active principles. Compounds 1 and 2 showed significant activity of DNA strand-scission with IC50 values of 10.8 and 7.5 μg/ml, respectively (positive control, bleomycin: IC50 3.3 μg/ml).

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalNatural Product Sciences
Issue number2
StatePublished - Jun 2003


  • (±)-catechin
  • (-)-epicatechin
  • DNA strand-scission
  • Leguminosae
  • Mucuna birdwoodiana


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