Abstract
Here, we report one-step DNA functionalization of hydrophobic iron oxide nanoparticles (IONPs) using DNA-grafted poly(acrylic acid) (PAA-g-DNA). PAA-g-DNA was synthesized by coupling PAA to amine-modified oligonucleotides via solid-phase amide chemistry, which yielded PAA grafted with multiple DNA strands with high graft efficiencies. Synthesized PAA-g-DNA was utilized as a phase-transfer and DNA functionalization agent for hydrophobic IONPs, taking advantage of unreacted carboxylic acid groups. The resulting DNA-modified IONPs were well dispersed in aqueous solutions and possessed DNA binding properties characteristic of polyvalent DNA nanostructures, showing that this approach provides a simple one-step method for DNA functionalization of hydrophobic IONPs.
| Original language | English |
|---|---|
| Pages (from-to) | 14342-14346 |
| Number of pages | 5 |
| Journal | Langmuir |
| Volume | 34 |
| Issue number | 47 |
| DOIs | |
| State | Published - 27 Nov 2018 |
Bibliographical note
Funding Information:This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2018R1A2B3001049) and the Science Research Center funded by the Korea government (MSIP) (no. NRF-2017R1A5A105365). We would like to thank Prof. Jean Bouffard for helpful advice for polymer syntheses.
Publisher Copyright:
Copyright © 2018 American Chemical Society.