DNA-Grafted Poly(acrylic acid) for One-Step DNA Functionalization of Iron Oxide Nanoparticles

Xiaole Hu, Chan Jin Kim, Shine K. Albert, So Jung Park

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Here, we report one-step DNA functionalization of hydrophobic iron oxide nanoparticles (IONPs) using DNA-grafted poly(acrylic acid) (PAA-g-DNA). PAA-g-DNA was synthesized by coupling PAA to amine-modified oligonucleotides via solid-phase amide chemistry, which yielded PAA grafted with multiple DNA strands with high graft efficiencies. Synthesized PAA-g-DNA was utilized as a phase-transfer and DNA functionalization agent for hydrophobic IONPs, taking advantage of unreacted carboxylic acid groups. The resulting DNA-modified IONPs were well dispersed in aqueous solutions and possessed DNA binding properties characteristic of polyvalent DNA nanostructures, showing that this approach provides a simple one-step method for DNA functionalization of hydrophobic IONPs.

Original languageEnglish
Pages (from-to)14342-14346
Number of pages5
Issue number47
StatePublished - 27 Nov 2018

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2018R1A2B3001049) and the Science Research Center funded by the Korea government (MSIP) (no. NRF-2017R1A5A105365). We would like to thank Prof. Jean Bouffard for helpful advice for polymer syntheses.

Publisher Copyright:
Copyright © 2018 American Chemical Society.


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