DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in an oxygen-saturated aqueous solution

Ikuo Nakanishi; Shunichi Fukuzumi; Toshifumi Konishi; Kei Ohkubo; Mamoru Fujitsuka; Osamu Ito; Naoki Miyata

doi:10.1021/jp013215j

DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C₆₀ in an oxygen-saturated aqueous solution

Ikuo Nakanishi, Shunichi Fukuzumi, Toshifumi Konishi, Kei Ohkubo, Mamoru Fujitsuka, Osamu Ito, Naoki Miyata

Department of Chemistry & Nanoscience

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88 Scopus citations

Abstract

The DNA cleavage via superoxide anion, formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C₆₀ in a oxygen-saturated aqueous solution, was discussed. The reorganization energy for the reduction of O₂ to O₂^.- was found to be 43.4 Kcal mol^-1. The analysis suggested that the electron transfer from C₆₀^.-/γ-CyD to O₂ proceeded via an outer sphere pathway.

Original language	English
Pages (from-to)	2372-2380
Number of pages	9
Journal	Journal of Physical Chemistry B
Volume	106
Issue number	9
DOIs	https://doi.org/10.1021/jp013215j
State	Published - 7 Mar 2002

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title = "DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in an oxygen-saturated aqueous solution",

abstract = "The DNA cleavage via superoxide anion, formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in a oxygen-saturated aqueous solution, was discussed. The reorganization energy for the reduction of O2 to O2.- was found to be 43.4 Kcal mol-1. The analysis suggested that the electron transfer from C60.-/γ-CyD to O2 proceeded via an outer sphere pathway.",

author = "Ikuo Nakanishi and Shunichi Fukuzumi and Toshifumi Konishi and Kei Ohkubo and Mamoru Fujitsuka and Osamu Ito and Naoki Miyata",

year = "2002",

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doi = "10.1021/jp013215j",

language = "English",

volume = "106",

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journal = "Journal of Physical Chemistry B",

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publisher = "American Chemical Society",

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DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C₆₀ in an oxygen-saturated aqueous solution. / Nakanishi, Ikuo; Fukuzumi, Shunichi; Konishi, Toshifumi et al.
In: Journal of Physical Chemistry B, Vol. 106, No. 9, 07.03.2002, p. 2372-2380.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in an oxygen-saturated aqueous solution

AU - Nakanishi, Ikuo

AU - Fukuzumi, Shunichi

AU - Konishi, Toshifumi

AU - Ohkubo, Kei

AU - Fujitsuka, Mamoru

AU - Ito, Osamu

AU - Miyata, Naoki

PY - 2002/3/7

Y1 - 2002/3/7

N2 - The DNA cleavage via superoxide anion, formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in a oxygen-saturated aqueous solution, was discussed. The reorganization energy for the reduction of O2 to O2.- was found to be 43.4 Kcal mol-1. The analysis suggested that the electron transfer from C60.-/γ-CyD to O2 proceeded via an outer sphere pathway.

AB - The DNA cleavage via superoxide anion, formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in a oxygen-saturated aqueous solution, was discussed. The reorganization energy for the reduction of O2 to O2.- was found to be 43.4 Kcal mol-1. The analysis suggested that the electron transfer from C60.-/γ-CyD to O2 proceeded via an outer sphere pathway.

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U2 - 10.1021/jp013215j

DO - 10.1021/jp013215j

M3 - Article

AN - SCOPUS:0037035210

SN - 1089-5647

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JF - Journal of Physical Chemistry B

IS - 9

ER -

DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C60 in an oxygen-saturated aqueous solution

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DNA cleavage via superoxide anion formed in photoinduced electron transfer from NADH to γ-cyclodextrin-bicapped C₆₀ in an oxygen-saturated aqueous solution