DMF as a source of oxygen and aminomethine: Stereoselective 1,2-insertion of rhodium(II) azavinyl carbenes into the C=O bond of formamides for the synthesis of cis -diamino enones

Da Jung Jung, Hyun Ji Jeon, Ju Hyun Kim, Youngmee Kim, Sang Gi Lee

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Abstract

A new catalytic reaction in which all the atoms of a formamide are incorporated into the product through a formal stereoselective 1,2-insertion of rhodium(II) azavinyl carbenes, generated in situ from readily available N-sulfonylated 1,2,3-triazoles, into the C=O bond of DMF and other N,N-disubstituted formamides to afford cis-diamino enones is described.

Original languageEnglish
Pages (from-to)2208-2211
Number of pages4
JournalOrganic Letters
Volume16
Issue number8
DOIs
StatePublished - 18 Apr 2014

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