TY - JOUR
T1 - DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled
AU - Yun, Sanguk
AU - Cha, Sun Shin
AU - Kim, Jae Ho
N1 - Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 202103890002 ), and NRF grants funded by the Korea government ( MSIT ) ( NRF-2022R1A5A102641311 & NRF-2022R1A2C3006924 ).
Publisher Copyright:
© 2022
PY - 2023/5
Y1 - 2023/5
N2 - DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) control, transcriptional regulation, chaperone function, fertility, and cell transformation. Herein, we report a novel function of DJ-1 in actin cytoskeletal rearrangements. DJ-1 was identified as a new binding partner of Mena, a protein of the Enah/VASP family, and it promoted cancer cell migration by Mena-dependent actin polymerization and filopodia formation. These results suggest a novel molecular mechanism for DJ-1-dependent cancer cell invasion and metastasis.
AB - DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) control, transcriptional regulation, chaperone function, fertility, and cell transformation. Herein, we report a novel function of DJ-1 in actin cytoskeletal rearrangements. DJ-1 was identified as a new binding partner of Mena, a protein of the Enah/VASP family, and it promoted cancer cell migration by Mena-dependent actin polymerization and filopodia formation. These results suggest a novel molecular mechanism for DJ-1-dependent cancer cell invasion and metastasis.
UR - http://www.scopus.com/inward/record.url?scp=85144363913&partnerID=8YFLogxK
U2 - 10.1016/j.jbior.2022.100943
DO - 10.1016/j.jbior.2022.100943
M3 - Article
C2 - 36542983
AN - SCOPUS:85144363913
SN - 2212-4926
VL - 88
JO - Advances in Biological Regulation
JF - Advances in Biological Regulation
M1 - 100943
ER -
