DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled

Sanguk Yun; Sun Shin Cha; Jae Ho Kim

doi:10.1016/j.jbior.2022.100943

DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled

Sanguk Yun, Sun Shin Cha, Jae Ho Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

Abstract

DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) control, transcriptional regulation, chaperone function, fertility, and cell transformation. Herein, we report a novel function of DJ-1 in actin cytoskeletal rearrangements. DJ-1 was identified as a new binding partner of Mena, a protein of the Enah/VASP family, and it promoted cancer cell migration by Mena-dependent actin polymerization and filopodia formation. These results suggest a novel molecular mechanism for DJ-1-dependent cancer cell invasion and metastasis.

Original language	English
Article number	100943
Journal	Advances in Biological Regulation
Volume	88
DOIs	https://doi.org/10.1016/j.jbior.2022.100943
State	Published - May 2023

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 202103890002 ), and NRF grants funded by the Korea government ( MSIT ) ( NRF-2022R1A5A102641311 & NRF-2022R1A2C3006924 ).

Publisher Copyright:
© 2022

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title = "DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled",

abstract = "DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) control, transcriptional regulation, chaperone function, fertility, and cell transformation. Herein, we report a novel function of DJ-1 in actin cytoskeletal rearrangements. DJ-1 was identified as a new binding partner of Mena, a protein of the Enah/VASP family, and it promoted cancer cell migration by Mena-dependent actin polymerization and filopodia formation. These results suggest a novel molecular mechanism for DJ-1-dependent cancer cell invasion and metastasis.",

author = "Sanguk Yun and Cha, {Sun Shin} and Kim, {Jae Ho}",

note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 202103890002 ), and NRF grants funded by the Korea government ( MSIT ) ( NRF-2022R1A5A102641311 & NRF-2022R1A2C3006924 ). Publisher Copyright: {\textcopyright} 2022",

year = "2023",

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doi = "10.1016/j.jbior.2022.100943",

language = "English",

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journal = "Advances in Biological Regulation",

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AU - Yun, Sanguk

AU - Cha, Sun Shin

AU - Kim, Jae Ho

N1 - Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 202103890002 ), and NRF grants funded by the Korea government ( MSIT ) ( NRF-2022R1A5A102641311 & NRF-2022R1A2C3006924 ). Publisher Copyright: © 2022

PY - 2023/5

Y1 - 2023/5

N2 - DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) control, transcriptional regulation, chaperone function, fertility, and cell transformation. Herein, we report a novel function of DJ-1 in actin cytoskeletal rearrangements. DJ-1 was identified as a new binding partner of Mena, a protein of the Enah/VASP family, and it promoted cancer cell migration by Mena-dependent actin polymerization and filopodia formation. These results suggest a novel molecular mechanism for DJ-1-dependent cancer cell invasion and metastasis.

AB - DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) control, transcriptional regulation, chaperone function, fertility, and cell transformation. Herein, we report a novel function of DJ-1 in actin cytoskeletal rearrangements. DJ-1 was identified as a new binding partner of Mena, a protein of the Enah/VASP family, and it promoted cancer cell migration by Mena-dependent actin polymerization and filopodia formation. These results suggest a novel molecular mechanism for DJ-1-dependent cancer cell invasion and metastasis.

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DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled

Abstract

Bibliographical note

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