Diversity-oriented synthesis of 2,4,6-trisubstituted piperidines via Type II Anion Relay Chemistry

Amos B. Smith, Heeoon Han, Won Suk Kim

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

An effective, general protocol for the Diversity-Oriented Synthesis (DOS) of 2,4,6-trisubstituted piperidine congeners has been designed and validated. The successful strategy entails a modular approach to all possible stereoisomers of the selected piperidine scaffold, exploiting Type II Anion Relay Chemistry (ARC), followed in turn by intramolecular SN2 cyclization, chemoselective removal of the dithiane moieties and carbonyl reductions.

Original languageEnglish
Pages (from-to)3328-3331
Number of pages4
JournalOrganic Letters
Volume13
Issue number13
DOIs
StatePublished - 1 Jul 2011

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