Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

Amos B. Smith; Won Suk Kim

doi:10.1073/pnas.1015265108

Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

Amos B. Smith
, Won Suk Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring "natural product-like" macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.

Original language	English
Pages (from-to)	6787-6792
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	108
Issue number	17
DOIs	https://doi.org/10.1073/pnas.1015265108
State	Published - 26 Apr 2011

Keywords

Benzyne cycloaddition
Natural product-like macrolides

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10.1073/pnas.1015265108

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abstract = "In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring {"}natural product-like{"} macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.",

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language = "English",

volume = "108",

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Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity. / Smith, Amos B.; Kim, Won Suk.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 17, 26.04.2011, p. 6787-6792.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

AU - Smith, Amos B.

AU - Kim, Won Suk

PY - 2011/4/26

Y1 - 2011/4/26

N2 - In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring "natural product-like" macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.

AB - In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring "natural product-like" macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.

KW - Benzyne cycloaddition

KW - Natural product-like macrolides

UR - https://www.scopus.com/pages/publications/79955566562

U2 - 10.1073/pnas.1015265108

DO - 10.1073/pnas.1015265108

M3 - Article

C2 - 21245309

AN - SCOPUS:79955566562

SN - 0027-8424

VL - 108

SP - 6787

EP - 6792

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 17

ER -

Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

Abstract

Keywords

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