Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

Amos B. Smith, Won Suk Kim

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring "natural product-like" macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.

Original languageEnglish
Pages (from-to)6787-6792
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number17
DOIs
StatePublished - 26 Apr 2011

Keywords

  • Benzyne cycloaddition
  • Natural product-like macrolides

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