TY - JOUR
T1 - Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity
AU - Smith, Amos B.
AU - Kim, Won Suk
PY - 2011/4/26
Y1 - 2011/4/26
N2 - In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring "natural product-like" macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.
AB - In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring "natural product-like" macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.
KW - Benzyne cycloaddition
KW - Natural product-like macrolides
UR - http://www.scopus.com/inward/record.url?scp=79955566562&partnerID=8YFLogxK
U2 - 10.1073/pnas.1015265108
DO - 10.1073/pnas.1015265108
M3 - Article
C2 - 21245309
AN - SCOPUS:79955566562
SN - 0027-8424
VL - 108
SP - 6787
EP - 6792
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 17
ER -