Disulfiram Treatment Normalizes Body Weight in Obese Mice

Michel Bernier; Sarah J. Mitchell; Devin Wahl; Antonio Diaz; Abhishek Singh; Wonhyo Seo; Mingy Wang; Ahmed Ali; Tamzin Kaiser; Nathan L. Price; Miguel A. Aon; Eun Young Kim; Michael A. Petr; Huan Cai; Alessa Warren; Clara Di Germanio; Andrea Di Francesco; Ken Fishbein; Vince Guiterrez; Dylan Harney; Yen Chin Koay; John Mach; Ignacio Navas Enamorado; Tamara Pulpitel; Yushi Wang; Jing Zhang; Li Zhang; Richard G. Spencer; Kevin G. Becker; Josephine M. Egan; Edward G. Lakatta; John O'Sullivan; Mark Larance; David G. LeCouteur; Victoria C. Cogger; Bin Gao; Carlos Fernandez-Hernando; Ana Maria Cuervo; Rafael de Cabo

doi:10.1016/j.cmet.2020.04.019

Disulfiram Treatment Normalizes Body Weight in Obese Mice

Michel Bernier, Sarah J. Mitchell, Devin Wahl, Antonio Diaz, Abhishek Singh, Wonhyo Seo, Mingy Wang, Ahmed Ali, Tamzin Kaiser, Nathan L. Price, Miguel A. Aon, Eun Young Kim, Michael A. Petr, Huan Cai, Alessa Warren, Clara Di Germanio, Andrea Di Francesco, Ken Fishbein, Vince Guiterrez, Dylan HarneyYen Chin Koay, John Mach, Ignacio Navas Enamorado, Tamara Pulpitel, Yushi Wang, Jing Zhang, Li Zhang, Richard G. Spencer, Kevin G. Becker, Josephine M. Egan, Edward G. Lakatta, John O'Sullivan, Mark Larance, David G. LeCouteur, Victoria C. Cogger, Bin Gao, Carlos Fernandez-Hernando, Ana Maria Cuervo, Rafael de Cabo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

In this study, Bernier et al. report on the off-label use of disulfiram to combat diet-induced obesity in mice through normalization of body weight and improvement of various physiological outcomes related to body composition and insulin responsiveness.

Original language	English
Pages (from-to)	203-214.e4
Journal	Cell Metabolism
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2020.04.019
State	Published - 4 Aug 2020

Bibliographical note

Publisher Copyright:
© 2020

Keywords

beta-cell hyperplasia
fibrosis
hepatic steatosis
inflammation
insulin resistance
obesity
weight gain

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10.1016/j.cmet.2020.04.019

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Bernier, M., Mitchell, S. J., Wahl, D., Diaz, A., Singh, A., Seo, W., Wang, M., Ali, A., Kaiser, T., Price, N. L., Aon, M. A., Kim, E. Y., Petr, M. A., Cai, H., Warren, A., Di Germanio, C., Di Francesco, A., Fishbein, K., Guiterrez, V., ... de Cabo, R. (2020). Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell Metabolism, 32(2), 203-214.e4. https://doi.org/10.1016/j.cmet.2020.04.019

@article{7c7e149ae46842438d49ae108d6b98b9,

title = "Disulfiram Treatment Normalizes Body Weight in Obese Mice",

abstract = "In this study, Bernier et al. report on the off-label use of disulfiram to combat diet-induced obesity in mice through normalization of body weight and improvement of various physiological outcomes related to body composition and insulin responsiveness.",

keywords = "beta-cell hyperplasia, fibrosis, hepatic steatosis, inflammation, insulin resistance, obesity, weight gain",

author = "Michel Bernier and Mitchell, \{Sarah J.\} and Devin Wahl and Antonio Diaz and Abhishek Singh and Wonhyo Seo and Mingy Wang and Ahmed Ali and Tamzin Kaiser and Price, \{Nathan L.\} and Aon, \{Miguel A.\} and Kim, \{Eun Young\} and Petr, \{Michael A.\} and Huan Cai and Alessa Warren and \{Di Germanio\}, Clara and \{Di Francesco\}, Andrea and Ken Fishbein and Vince Guiterrez and Dylan Harney and Koay, \{Yen Chin\} and John Mach and Enamorado, \{Ignacio Navas\} and Tamara Pulpitel and Yushi Wang and Jing Zhang and Li Zhang and Spencer, \{Richard G.\} and Becker, \{Kevin G.\} and Egan, \{Josephine M.\} and Lakatta, \{Edward G.\} and John O'Sullivan and Mark Larance and LeCouteur, \{David G.\} and Cogger, \{Victoria C.\} and Bin Gao and Carlos Fernandez-Hernando and Cuervo, \{Ana Maria\} and \{de Cabo\}, Rafael",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = aug,

day = "4",

doi = "10.1016/j.cmet.2020.04.019",

language = "English",

volume = "32",

pages = "203--214.e4",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "2",

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Bernier, M, Mitchell, SJ, Wahl, D, Diaz, A, Singh, A, Seo, W, Wang, M, Ali, A, Kaiser, T, Price, NL, Aon, MA, Kim, EY, Petr, MA, Cai, H, Warren, A, Di Germanio, C, Di Francesco, A, Fishbein, K, Guiterrez, V, Harney, D, Koay, YC, Mach, J, Enamorado, IN, Pulpitel, T, Wang, Y, Zhang, J, Zhang, L, Spencer, RG, Becker, KG, Egan, JM, Lakatta, EG, O'Sullivan, J, Larance, M, LeCouteur, DG, Cogger, VC, Gao, B, Fernandez-Hernando, C, Cuervo, AM & de Cabo, R 2020, 'Disulfiram Treatment Normalizes Body Weight in Obese Mice', Cell Metabolism, vol. 32, no. 2, pp. 203-214.e4. https://doi.org/10.1016/j.cmet.2020.04.019

TY - JOUR

T1 - Disulfiram Treatment Normalizes Body Weight in Obese Mice

AU - Bernier, Michel

AU - Mitchell, Sarah J.

AU - Wahl, Devin

AU - Diaz, Antonio

AU - Singh, Abhishek

AU - Seo, Wonhyo

AU - Wang, Mingy

AU - Ali, Ahmed

AU - Kaiser, Tamzin

AU - Price, Nathan L.

AU - Aon, Miguel A.

AU - Kim, Eun Young

AU - Petr, Michael A.

AU - Cai, Huan

AU - Warren, Alessa

AU - Di Germanio, Clara

AU - Di Francesco, Andrea

AU - Fishbein, Ken

AU - Guiterrez, Vince

AU - Harney, Dylan

AU - Koay, Yen Chin

AU - Mach, John

AU - Enamorado, Ignacio Navas

AU - Pulpitel, Tamara

AU - Wang, Yushi

AU - Zhang, Jing

AU - Zhang, Li

AU - Spencer, Richard G.

AU - Becker, Kevin G.

AU - Egan, Josephine M.

AU - Lakatta, Edward G.

AU - O'Sullivan, John

AU - Larance, Mark

AU - LeCouteur, David G.

AU - Cogger, Victoria C.

AU - Gao, Bin

AU - Fernandez-Hernando, Carlos

AU - Cuervo, Ana Maria

AU - de Cabo, Rafael

PY - 2020/8/4

Y1 - 2020/8/4

N2 - In this study, Bernier et al. report on the off-label use of disulfiram to combat diet-induced obesity in mice through normalization of body weight and improvement of various physiological outcomes related to body composition and insulin responsiveness.

AB - In this study, Bernier et al. report on the off-label use of disulfiram to combat diet-induced obesity in mice through normalization of body weight and improvement of various physiological outcomes related to body composition and insulin responsiveness.

KW - beta-cell hyperplasia

KW - fibrosis

KW - hepatic steatosis

KW - inflammation

KW - insulin resistance

KW - obesity

KW - weight gain

UR - https://www.scopus.com/pages/publications/85085490708

U2 - 10.1016/j.cmet.2020.04.019

DO - 10.1016/j.cmet.2020.04.019

M3 - Article

C2 - 32413333

AN - SCOPUS:85085490708

SN - 1550-4131

VL - 32

SP - 203-214.e4

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

Disulfiram Treatment Normalizes Body Weight in Obese Mice

Abstract

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Keywords

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