@article{7c7e149ae46842438d49ae108d6b98b9,
title = "Disulfiram Treatment Normalizes Body Weight in Obese Mice",
abstract = "In this study, Bernier et al. report on the off-label use of disulfiram to combat diet-induced obesity in mice through normalization of body weight and improvement of various physiological outcomes related to body composition and insulin responsiveness.",
keywords = "beta-cell hyperplasia, fibrosis, hepatic steatosis, inflammation, insulin resistance, obesity, weight gain",
author = "Michel Bernier and Mitchell, {Sarah J.} and Devin Wahl and Antonio Diaz and Abhishek Singh and Wonhyo Seo and Mingy Wang and Ahmed Ali and Tamzin Kaiser and Price, {Nathan L.} and Aon, {Miguel A.} and Kim, {Eun Young} and Petr, {Michael A.} and Huan Cai and Alessa Warren and {Di Germanio}, Clara and {Di Francesco}, Andrea and Ken Fishbein and Vince Guiterrez and Dylan Harney and Koay, {Yen Chin} and John Mach and Enamorado, {Ignacio Navas} and Tamara Pulpitel and Yushi Wang and Jing Zhang and Li Zhang and Spencer, {Richard G.} and Becker, {Kevin G.} and Egan, {Josephine M.} and Lakatta, {Edward G.} and John O'Sullivan and Mark Larance and LeCouteur, {David G.} and Cogger, {Victoria C.} and Bin Gao and Carlos Fernandez-Hernando and Cuervo, {Ana Maria} and {de Cabo}, Rafael",
note = "Funding Information: This work was supported by funding from the Intramural Research Program of the National Institute on Aging /NIH and NIH award R35HL135820 (C.F.-H.). This work was also supported by NIH/ NIA grants AG031782 and AG038072 (A.M.C.). S.J.M. was supported by a National Medical Health and Research Council of Australia CJ Martin Early Career Fellowship (RGMS ID 2010-01671 ). M.L. is a Cancer Institute New South Wales Future Research Leader Fellow (15/FRL/1-06A). This work was supported by grants from the NHMRC ( APP1120475 ). E.Y.K. was supported by a grant from the KRIBB Research Initiative Program (Korean Biomedical Scientist Fellowship Program), Korea Research Institute of Bioscience and Biotechnology, Republic of Korea. Special thanks to the members of the Translational Gerontology Branch, Laboratory of Clinical Investigation, and the Comparative Medicine Section of the National Institute on Aging. We are particularly grateful to Dawn Nines, Dawn Boyer, Olga Carlson, and Alice E. Kane for their excellent work, as well as to Marc Raley at NIA Visual Media Service. Funding Information: This work was supported by funding from the Intramural Research Program of the National Institute on Aging/NIH and NIH award R35HL135820 (C.F.-H.). This work was also supported by NIH/NIA grants AG031782 and AG038072 (A.M.C.). S.J.M. was supported by a National Medical Health and Research Council of Australia CJ Martin Early Career Fellowship (RGMS ID 2010-01671). M.L. is a Cancer Institute New South Wales Future Research Leader Fellow (15/FRL/1-06A). This work was supported by grants from the NHMRC (APP1120475). E.Y.K. was supported by a grant from the KRIBB Research Initiative Program (Korean Biomedical Scientist Fellowship Program), Korea Research Institute of Bioscience and Biotechnology, Republic of Korea. Special thanks to the members of the Translational Gerontology Branch, Laboratory of Clinical Investigation, and the Comparative Medicine Section of the National Institute on Aging. We are particularly grateful to Dawn Nines, Dawn Boyer, Olga Carlson, and Alice E. Kane for their excellent work, as well as to Marc Raley at NIA Visual Media Service. M.B. S.J.M. and R.d.C. designed the study; S.J.M. and the remaining authors performed critical experiments in mice or rats and/or were involved in either histochemical, scanning electron microscopy, or high-density microscopy. M.B. took the leading role in writing the manuscript and creating the figures; M.B. R.d.C. and A.M.C. contributed to the editing and proof-reading of the final draft. R.d.C. and M.B. supervised the study. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020",
year = "2020",
month = aug,
day = "4",
doi = "10.1016/j.cmet.2020.04.019",
language = "English",
volume = "32",
pages = "203--214.e4",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",
}